快速崩解口服片中溶剂蒸发掩味微胶囊技术的研究

N. Belali, A. Chaerunisaa
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引用次数: 2

摘要

微胶囊化技术是当今时代应用广泛的一项技术,已被应用于制药、农业、化妆品、食品等各个领域。它可以将液体或固体物质包裹在聚合物涂层中,以达到掩盖味道、控制释放和提高稳定性等目的。微胶囊化可以通过不同的途径和方法来实现,但溶剂蒸发是最常用的一种可行的方法。溶剂蒸发是在乳化、溶剂蒸发和萃取微球的基础上发展起来的,近年来为了提高微球的收率和性能,对该技术进行了许多改进。溶剂蒸发已广泛应用于不同用途的微胶囊,其中之一是快速崩解口服片剂中苦味药物的掩味。FDTs因其优点和应用于吞咽困难患者的可行性而备受关注,同时它还可以提高药物的生物利用度和作用时间。本文主要综述了溶剂蒸发技术在快速崩解口服片生产中对苦味药物进行掩味的应用。本文综述了溶剂蒸发技术、制备技术、所用材料及其相对于其他微胶囊掩味方法的优缺点。关键词:微胶囊,溶剂蒸发,fdt,萃取,微球
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Solvent Evaporation as an Efficient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets
Microencapsulation is an extensively used technology of present era, that has been applied to various fields like pharmaceutical industry, agriculture, cosmetics and food technology. With the help of which liquid or solid material can be encapsulated inside a polymeric coating film for various reasons such as taste masking, control release and enhancing stability and etc. Microencapsulation can be achieved with different approaches and methods but one of the popular and frequently used feasible method is Solvent evaporation. Solvent evaporation is based on emulsification, solvent evaporation and extraction of microspheres, recently many variations have been made in this technology to improve the yield and properties of microspheres. Solvent evaporation has been widely used in microencapsulating for different purposes one of which is taste masking of bitter drugs in fast disintegrating oral tablets, for pediatric and geriatric use. FDTs are center of attraction due to their merits and feasibility of use for people with problem of dysphagia at the same time, it can also improve bioavailability and time of action of drugs. The main focus of current review is use of solvent evaporation technique for taste masking of bitter drugs in production of fast disintegrating oral tablets. In this review, we will summarize uses, novelties and variations in Solvent Evaporation technique, preparation technique, materials used, merits and demerits of this method over other microencapsulation method in taste masking.Keywords: Microencapsulation, Solvent Evaporation, FDTs, extraction, microspheres
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