The combination of intermittent caloric restriction and moderate-intensity interval training in decreasing blood glucose and CRP levels with a high glycemic index diet

This study aims to analyze the effect of the combination of intermittent calorie restriction and moderate intensity interval training (MIIT) on serum c-reactive protein (CRP) levels as one of the inflammatory mediators and blood glucose levels in female mice exposed to a-high glycemic index diet. The sample of this study was female mice Balb/c strain, divided into four groups:, the control group (con), the intermittent calorie restriction group (restrict), the MIIT group (interv), and the combine group of intermittent calorie restriction and moderate-intensity interval training (restrict+interv). A high glycemic index diet was a high calorie and was provided by standard feed and oral gavage of 0.013 g/gBW glucosesolution. Intermittent calorie restriction was 50% reduction of the standard feed 3x/week. The MIIT was five-minute intervals of swimming and 30 seconds of passive rest consecutively for 30 minutes and 3x/week. Meanwhile, the treatment duration was four weeks. The oral glucose tolerance test consisting of fasting blood glucose (FBG) and a two-hour post -prandial (2HPP) blood glucose was measured before and after the treatment. CRP was examined only after the treatment. The restrict + interv group had a significant reduction in CRP levels compared to the restricted group (p = 0.005) and the interv group (p = 0.044). The FBG levels the restrict + interv group and restricted group had a significant decrease (p = 0.026). Moreover, 2HPP of the restrict + interv group and restricted group had a significant decline (p = 0.000). This study concludes that the combination of intermittent calorie restriction and moderate -intensity interval training can attenuate elevated serum CRP and blood glucose levels.