Receptors of advanced glycation end products in oral squamous cell carcinoma: A systematic review

Oxidative stress markers have been shown to be elevated in oral squamous cell carcinomas; plays a crucial role in the build-up of advanced glycation end-receptors of advanced glycation end (AGE-RAGE) products; and has been shown to exacerbate cellular dysfunction, vascular change, apoptosis, and activate inflammatory pathways. The purpose of this study is to assess comprehensively the involvement of RAGE in oral squamous cell malignancies. The findings imply that these receptors and their associated ligands play a significant role in the growth and spread of the tumor, hence impacting the prognosis and life expectancy of the affected individual. This comprehensive review uncovers promising evidence for the clinical use of these molecules, such as RAGEs, in prognostic considerations or as molecular targets for therapy. The available literature shows a role for RAGE in invasion, migration, and angiogenesis in oral cancers. These preliminary findings are encouraging for the therapeutic use of these molecules for prognostic considerations or molecularly targeted therapy.