Fatemeh Javani Jouni, Jaber Zafari, Elahe Shams, P. Abdolmaleki, A. Rastegari
{"title":"海眼镜蛇(Naja Naja xiana)蛇毒与阿霉素在HeLa癌细胞系和正常HFF成纤维细胞中的抗癌作用比较","authors":"Fatemeh Javani Jouni, Jaber Zafari, Elahe Shams, P. Abdolmaleki, A. Rastegari","doi":"10.52547/sjimu.29.6.20","DOIUrl":null,"url":null,"abstract":"most to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19). Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h. Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"134 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Anti-Cancer Effects of Caspian Cobra (Naja naja oxiana) Snake Venom in Comparison with Doxorubicin in HeLa Cancer Cell Line and Normal HFF Fibroblast\",\"authors\":\"Fatemeh Javani Jouni, Jaber Zafari, Elahe Shams, P. Abdolmaleki, A. Rastegari\",\"doi\":\"10.52547/sjimu.29.6.20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"most to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19). Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h. Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.\",\"PeriodicalId\":16041,\"journal\":{\"name\":\"journal of ilam university of medical sciences\",\"volume\":\"134 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"journal of ilam university of medical sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52547/sjimu.29.6.20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"journal of ilam university of medical sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52547/sjimu.29.6.20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of Anti-Cancer Effects of Caspian Cobra (Naja naja oxiana) Snake Venom in Comparison with Doxorubicin in HeLa Cancer Cell Line and Normal HFF Fibroblast
most to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19). Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h. Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.
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