早期静脉脂乳治疗苯海拉明过量1例

Toxicology communications Pub Date : 2021-01-01 DOI:10.1080/24734306.2020.1870078

J. Clemons, Arvinder Jandu, B. Stein, Michael A. Chary

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引用次数: 3

摘要

苯海拉明(DPH)是一种组胺受体的亲脂性逆激动剂。过量通常表现为抗胆碱能症状。大剂量过量可发生广泛性复杂心动过速失代偿导致心血管衰竭。在此，我们报告了一位患者在摄入83 mg/kg苯海拉明后出现室性心律失常，进入心血管衰竭，并通过早期静脉注射脂质乳获救。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report

Abstract Diphenhydramine (DPH) is a lipophilic inverse agonist at the histamine receptor. Overdoses usually present with anticholinergic symptoms. Wide-complex tachycardia decompensating into cardiovascular collapse may occur in larger overdoses. Here we report a patient who developed ventricular dysrhythmias after ingestion of 83 mg/kg of diphenhydramine, went into cardiovascular collapse that was rescued with early administration of intravenous lipid emulsion.

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Toxicology communications

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