酵母DNA芯片对环境水体的评价

IF 0.4 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Chem-Bio Informatics Journal Pub Date : 2006-01-01 DOI:10.1273/CBIJ.6.29
Y. Murata, Satomi Murata-Mizukami, E. Kitagawa, H. Iwahashi, K. Takamizawa
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引用次数: 2

摘要

我们提出了一种利用DNA芯片技术评价环境水的新方法。从焚烧过程、一些工厂和各种土壤中取样了21种环境水。我们利用DNA微阵列进行了全面的分析,并尝试用层次聚类分析对环境水样进行分类。这些水样根据化学物质和物理应力条件从A到F分为几类。聚在A簇中的水样会引起蛋白质变性和氧化应激,但不会引起突变。聚在簇B中的水样导致蛋白质变性。归入簇C的水样引起突变、蛋白质变性和细胞壁损伤。聚在聚类D中的水样引起突变。聚在E簇中的水样引起蛋白质变性和氧化应激。聚在F群中的水样引起氧化应激。因此,可以通过层次聚类分析对环境水的潜在影响进行估计。
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The evaluation of environmental waters using yeast DNA microarray
We propose a new method for the evaluation of environmental water by using DNA microarray technology. Twenty-one types of environmental waters were sampled from incineration processes, some factories, and various soils. We performed a comprehensive analysis by DNA microarray, and attempted to classify the environmental water samples by hierarchical cluster analysis. These water samples were classified into clusters from A to F together with chemicals and physical stress conditions. The water sample that grouped into cluster A caused protein denaturation and oxidative stress, but not mutagenesis. The water samples that grouped into cluster B caused protein denaturation. The water samples that grouped into cluster C caused mutagenesis, protein denaturation, and cell wall damage. The water samples that grouped into cluster D caused mutagenesis. The water samples that grouped into cluster E caused protein denaturation and oxidative stress. The water samples that grouped into cluster F caused oxidative stress. Consequently, the potential influences of environmental water could be estimated by hierarchical cluster analysis.
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来源期刊
Chem-Bio Informatics Journal
Chem-Bio Informatics Journal BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
0.60
自引率
0.00%
发文量
8
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