Forcespinning®nopal复合纳米纤维的细胞增殖特性

IF 2.1 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Bioactive and Compatible Polymers Pub Date : 2021-11-23 DOI:10.1177/08839115211060404

Cristobal Rodriguez, Victoria Padilla, K. Lozano, Fariha Ahmad, Alejandra Chapa, Alexa Villarreal, Andrew McDonald, L. Materon, R. Gilkerson

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引用次数: 2

摘要

在本研究中，采用Forcespinning®制备了由麻豆、“nopal”、黏液(N)提取物、壳聚糖(CH)和普鲁兰(PL) (N/CH/PL)组成的纳米纤维。研究了这些含nopal纳米纤维维持小鼠胚胎成纤维细胞(NIH 3T3)粘附和增殖的能力。经过6天的孵育，N/CH/PL纳米纤维显示出强劲的细胞增殖，在延长的孵育14天后，细胞继续生长。这些结果表明，天然生物活性化合物可以与可生物降解聚合物结合，为细胞生长提供更好的环境，这表明天然活性成分可能成为伤口敷料的替代品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cell proliferative properties of Forcespinning® nopal composite nanofibers

In this study, Forcespinning® was used to produce nanofibers composed of Opuntia cochenillifera, “nopal,” mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL). These nopal-incorporating nanofibers were examined for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, with continued cell growth after an extended incubation period of 14 days. These results demonstrate that natural bioactive compounds can be combined with biodegradable polymers to provide an enhanced environment for cell growth, suggesting potential natural active ingredients as alternatives in wound dressings.

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来源期刊

Journal of Bioactive and Compatible Polymers 工程技术-材料科学：生物材料

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).