Role of Branched Chain Amino Acid and Glycine in Prediabetes and Type II Diabetes Mellitus

2 National Diabetes center, Mustansiriyah University, Iraq *Corresponding author: Israaalhelo2@gmail.com (Rasheed) Abstract “Prediabetes is the term used for people whose glucose levels do not meet the diabetes criteria but is too high to be considered normal. Prediabetes patients should not be regarded as a clinical entity in their own right, but rather as an increased risk of diabetes and cardiovascular disease (CVD) ,It is linked to obesity (especially abdominal or visceral obesity), high triglyceride dyslipidemia and/or low HDL cholesterol, and hypertension. Branched-chain amino acids (BCAAs) are essential amino acids that include Valine, Leucine, and isoleucine, glycine is non-essential amino acids. Recent studied show that (BCAA) increased positively with insulin resistance and glycine work inversely this make a predictive for Type 2 DM. the present study show a higher significance increase of BCAA in prediabetes patients compared to control and lower significance decrease of glycine in prediabetes compared to control. In conclusion Amino acid and glucose metabolism are closely linked; amino acids represent a main reservoir for gluconeogenesis and influence insulin and glucagon secretion. Both processes are altered early in the pathogenesis of T2D, which, at least in theory, makes amino acids good candidates for biomarkers in this area.