口腔扁平苔藓患者唾液opiorphin的测定

Z. Dalirsani, M. Amirchaghmaghi, A. Ghazi, S. Hashemy, Mahboobeh Taherizadeh
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引用次数: 1

摘要

Opiorphin是一种五肽,可以从人体体液中分离出来,对疼痛有减轻作用。目的:由于扁平苔藓是一种慢性粘膜皮肤病,引起口腔黏膜疼痛或灼烧感,本研究旨在比较口腔扁平苔藓(OLP)患者与健康者唾液中opiorphin的水平。方法:选取24例OLP病变患者和21例健康人进行病例对照研究。收集未刺激唾液后,通过统计分析比较两组之间的opiorphin水平。结果:OLP患者唾液中opiorphin浓度与健康者比较差异无统计学意义(p=0.378)。此外,在OLP组,opiorphin浓度在男女之间无显著差异(p=0.601)。分析分析显示不同严重程度OLP病变的唾液opiorphin水平无显著差异(p=0.653)。结论:在本研究中,OLP患者的唾液opiorphin水平与健康受试者无显著差异;然而,为了更好地评估不同类型OLP病变的唾液opiorphin水平及其与疼痛严重程度的相关性,建议进行更多的研究。
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Assessment of salivary opiorphin in oral lichen planus
Opiorphin is a pentapeptide, which could be isolated from human fluids and has a decreasing effect on pain. Aim: Since lichen planus is a chronic mucocutaneous disease, which causes pain or burning feeling in the oral mucosa, this study aimed to compare salivary opiorphin levels of oral lichen planus (OLP) patients with healthy subjects. Methods: This case-control study, was performed on 24 patients with OLP lesions and 21 healthy subjects. After collecting unstimulated saliva, opiorphin levels were compared between two groups through statistical analyses. Results: There was not any significant difference between OLP patients and healthy subjects according to salivary opiorphin concentration (p=0.378). Also, in the OLP group, opiorphin concentration was not significantly different between males and females (p=0.601). Analytical analysis could not show any remarkable difference between various severity of OLP lesions regarding to salivary opiorphin levels (p=0.653). Conclusion: In this study, salivary opiorphin levels was not significantly different between patients with OLP and healthy subjects; however, more studies are suggested for better assessment of salivary opiorphin levels in various types of OLP lesions and its correlation with pain severity.
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来源期刊
Brazilian Journal of Oral Sciences
Brazilian Journal of Oral Sciences Dentistry-Dentistry (all)
CiteScore
0.60
自引率
0.00%
发文量
52
审稿时长
20 weeks
期刊介绍: The Brazilian Journal of Oral Sciences is an international non-profit journal, which publishes full-Length papers, original research reports, literature reviews, special reports, clinical cases, current topics and short communications, dealing with dentistry or related disciplines.
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