Q4 Pharmacology, Toxicology and Pharmaceutics Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2023-02-01 DOI:10.52794/hujpharm.1102486
Kenan Can Tok, Gökhun Çağatay Erbi̇l, Şeyda Yayla, Merve Eylül Kiymaci, M. M. Hürkul
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引用次数: 0

摘要

本研究考察了小球藻甲醇和丙酮提取物的抑菌活性。通过GC/MS分析明确了提取物的化学成分。采用微量肉汤稀释法测定小球藻提取物对枯草芽孢杆菌ATCC 6633、粪肠球菌ATCC 29212、大肠杆菌ATCC 25922、铜绿假单胞菌ATCC 27853、金黄色葡萄球菌ATCC 29213的最低抑菌浓度。结果表明,在一定浓度下,小球藻甲醇和丙酮提取物对枯草芽孢杆菌ATCC 6633(分别为625µg/ml和1250µg/ml)、粪肠杆菌ATCC 29212(分别为>5000µg/ml和1250µg/ml)、大肠杆菌ATCC 25922(>5000µg/ml)、铜绿假单胞菌ATCC 27853(>5000µg/ml)、金黄色葡萄球菌ATCC 29213(2500µg/ml)均有抑菌活性。化学分析表明,甲醇和丙酮提取物中脂肪酸含量较高,分别为33.22%和40.41%。在显示抗病原微生物活性的替代方法中,藻类是一种很好的天然资源。本研究表明,小球藻富含脂肪酸,具有天然抗菌的潜力。
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Chlorella sp. Kültürünün Ham Ekstrelerinin Kimyasal İçeriği ve Antibakteriyel Aktivitesi
In this study, the antibacterial activity of methanol and acetone extracts of Chlorella sp. was examined. The chemical contents of the extracts were clarified by GC/MS analysis. Antibacterial activity of Chlorella sp. extracts was determined as a minimum inhibitory concentration by broth microdilution method against Bacillus subtilis ATCC 6633, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213. It was found that methanol and acetone extracts of Chlorella sp. showed antibacterial activity against B. subtilis ATCC 6633 (625 µg/ml and 1250 µg/ml, respectively), E. faecalis ATCC 29212 (>5000 µg/ml and 1250 µg/ml, respectively), E. coli ATCC 25922 (>5000 µg/ml), P. aeruginosa ATCC 27853 (>5000 µg/ml), S. aureus ATCC 29213 (2500 µg/ml) at the specified concentrations. In the chemical analysis of the extracts, it was determined that the fatty acids were in high amounts, 33.22% and 40.41%, respectively, in the methanol and acetone extracts. Among the alternative methods to show activity against pathogenic microorganisms, algae can be a good natural resource. This study showed that Chlorella sp. contains high fatty acids and has potential as an antibacterial agent of natural origin.
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来源期刊
Hacettepe University Journal of the Faculty of Pharmacy
Hacettepe University Journal of the Faculty of Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.60
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0.00%
发文量
18
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