同种异体生物材料对心肌纤维变性后心肌结构的改善

A. Lebedeva, S. Afanasiev, E. M. Gareev, D. Kondratieva, L. A. Musina, S. V. Popov, A. Prusakov, A. Yashin, V. S. Ponamarev, V. D. Radnatarov
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摘要

介绍。缺血后心肌恢复可能性的问题仍然是相关的。本研究旨在研究分散脱细胞异体细胞外基质(allogeneic biomaterial, DAB)对心肌纤维变性的影响,并揭示其可能的细胞再生机制。材料和方法。对大鼠心脏肌壁进行冷冻破坏。45 d后,主组大鼠在病变心肌区注射异体生物材料混悬液,对照组大鼠注射生理盐水。结果和讨论。实验组已形成的纤维结缔组织退化,祖细胞的化学吸引,分化并整合到心肌中。与对照组相比,大鼠左心室壁肌部厚度增加了3个数量级。对研究结果的分析表明,成年哺乳动物的心脏具有强大的再生储备。很可能,基于DAB的使用,可以开发出一种方案,即使在已经发生纤维变性的情况下也可以恢复心肌。
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Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial
Introduction. The question of the possibility of recovery of postischemic myocardium remains relevant.Aim. The aim of the study was to study the effect of dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on the developed fibrous degeneration of the myocardium, as well as to reveal the possible mechanisms of cellular regeneration.Materials and methods. The muscular wall of the heart of rats was subjected to cryodestruction. After 45 days, the rats of the main group were intramyocardially injected with a suspension of allogeneic biomaterialinto the area of the affected myocardium, and the rats of the control group were injected with saline.Results and discussions. In the experimental group, there was a regression of the formed fibrous connective tissue, chemoattraction of progenitor cells, their differentiation and integration into the myocardium. The thickness of the muscular part of the wall of the left ventricle was three orders of magnitude higher than in the control group.Conclusion. Analysis of the results of the study indicates that the heart in adult mammals has a powerful regenerative reserve. It is likely that, based on the use of DAB, a protocol can be developed that allows the restoration of the heart muscle even in conditions of already developed fibrous degeneration.
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