Concordancia de índice cFFR con el FFR con adenosina intracoronaria en la práctica real

Introduction

Recently, there has been renewed interest in new coronary physiological indexes. Our aim was to investigate the correlation of resting baseline Pd/Pa and cFFR with FFR in real life patients and to test the accuracy of Pd/Pa and cFFR compare to FFR.

Material and methods

Multicenter prospective Study of patients with intermediate coronary stenosis functionally assessed by the ratio of distal coronary pressure and aortic pressure at rest (Pd/Pa), FFR and cFFR.

Results

70 patients (80 coronary lesions) were enrolled. Pd/Pa(r=0.82, P<.001) and cFFR (r=0.89, P<.001) showed a good correlation with FFR.

Based on the established FFR cutoff threshold of 0.8 to define a positive result, 44 (55%) lesions were functionally significant

ROC curve analysis of Pd/Pa and cFFR showed an area under the curve of 0.91 (95% IC 0.85-0.98) and 0.91 (95% IC 0.85-0.97) respectively.

The best cutoff values were >0.92 and >0.85 showing both of them a negative predictive value of 80%, a sensitivity of 84% and a specificity of 75% and 83% respectively.

Conclusions

Pd/PA but specially cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow, in some cases, avoid the use of adenosine savings costs and time.