固体脂质纳米颗粒在经皮贴剂给药中的应用综述

Rabnoor Alam, K. ., Aastha Arora, Harsh Gupta, P. Sharma
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引用次数: 0

摘要

透皮贴片用于通过皮肤输送药物来治疗整个疾病。这些取决于皮肤对编码药物的独特尺寸特性,固体脂质纳米颗粒(SLN)目前有机会创造用于药物传输的新型治疗特性,SLN靶向具有巨大的目标实现潜力,一个处罚区域,SLN在透皮贴片中加载的许多方面增加了渗透机制,配方,表征参数,SLN的未来优势,局限性,具有更好的生物相容性,低危害,sln在物理上是稳定的,并且对亲脂性药物有更好的递送。sln是脂质体和聚合物载体的混合物,可用于包封脂质和水溶性药物。SLN是一种可以扩大规模的低成本产品。它们的寿命也很长,可以通过使用不同的脂质来定制。由于sln具有多种重要的特性,当有效的药物递送载体以及脂质体药物递送的前景严重依赖于它们时,sln也开始出现。许多与sln相关的专利已经提交,还有更多基于sln的传输系统即将发明。
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A REVIEW ON THE APPLICATION OF SOLID LIPID NANOPARTICLES IN TRANSDERMAL PATCH DRUG DELIVERY
The transdermal patches are used to deliver medication through the skin to treat the entire ailment. These depend on a unique size property of skins to encoded drugs solid lipid nanoparticles (SLNs) current a chance to create upon novel therapeutic properties used for drugs transmission SLN targeting holds great potential for target achieving, a penalty area, Many aspects of the loaded of SLN sin transdermal patches for increasing mechanism of penetration, formulation, characterization parameters, future advantages, limitations of SLNs, had better biocompatibility, low harmfulness, SLNs is physically stable, and better delivery for Lipophilic drugs are discussed here. SLNs are a hybrid of liposomes and polymer-based carriers that could be used to encapsulate both lipid and water-soluble medicines. SLN is a low-cost product that can be scaled up. They also have a long-life span and could be customized by using different lipids. Because of their multiple significant qualities, SLNs also started to emerge when effective drug delivery carriers, as well as the prospect with liposome delivery of drugs, depends heavily on them. Many patents relating to SLNs have already been submitted, there are more invented SLN-based delivery systems on the way soon.
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