由本刊编辑从本刊精选的重要文章

Q2 Biochemistry, Genetics and Molecular Biology Clinical and Vaccine Immunology Pub Date : 2017-02-01 DOI:10.1128/CVI.00573-16

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引用次数: 0

摘要

功能性和抗原特异性血清抗体与人类志贺氏菌感染保护的相关性免疫保护志贺氏菌病仍然不明确。Shimanovich等人(e00412-16)建立了定量测定志贺氏菌特异性血清杀菌抗体(SBA)和抗噬细胞杀伤抗体(OPKA)的方法，并证明SBA和OPKA滴度以及IpaBand virg特异性IgG (IgG1)滴度与接种ecsf2a -2疫苗和未接种志贺氏菌flexneri 2a的志愿者的疾病减少显著相关。在临床研究中，候选减毒活疫苗CVD 1204和CVD 1208S也能引起SBA和OPKA反应。这是首次证明SBA、OPKA和IpaBand virg特异性IgG滴度与人类抗志贺氏菌病相关。这些发现对评价保护性免疫和疫苗效力具有重要意义。

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Articles of Significant Interest Selected from This Issue by the Editors

Functional and Antigen-Specific Serum Antibodies Correlate with Protection against Shigella Infection in Humans Immunological correlates of protection against shigellosis remain ill defined. Shimanovich et al. (e00412-16) establish quantitative assays to measure Shigella-specific serum bactericidal antibody (SBA) and opsonophagocytic killing antibody (OPKA) and demonstrate that SBA and OPKA titers, as well as IpaBand VirG-specific IgG (IgG1) titers, are significantly correlated with reduced disease in EcSf2a-2-vaccinated and unvaccinated volunteers challenged with virulent Shigella flexneri 2a. Live-attenuated vaccine candidates CVD 1204 and CVD 1208S also elicit SBA and OPKA responses in clinical studies. This is the first demonstration of SBA, OPKA, and IpaBand VirG-specific IgG titers being associated with protection against shigellosis in humans. These findings are relevant for evaluation of protective immunity and vaccine efficacy.

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来源期刊

Clinical and Vaccine Immunology 医学-传染病学

CiteScore

2.88

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： Cessation. First launched as Clinical and Diagnostic Laboratory Immunology (CDLI) in 1994, CVI published articles that enhanced the understanding of the immune response in health and disease and after vaccination by showcasing discoveries in clinical, laboratory, and vaccine immunology. CVI was committed to advancing all aspects of vaccine research and immunization, including discovery of new vaccine antigens and vaccine design, development and evaluation of vaccines in animal models and in humans, characterization of immune responses and mechanisms of vaccine action, controlled challenge studies to assess vaccine efficacy, study of vaccine vectors, adjuvants, and immunomodulators, immune correlates of protection, and clinical trials.