为生存分析选择统计检验

I. Etikan, Kamila Bukirova, Meliz Yuvalı
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引用次数: 10

摘要

生存分析是一种非常特殊的统计分析。生存分析的目的不是分析事件本身,而是分析到事件发生所经过的时间。这个相关时间也称为故障时间或生存时间。生存分析中使用的时间可能以不同的间隔测量:天、月、周、年等。冗长的研究当然更适合分析,因为它们提供了更有力的证据和更可靠的结果。然而,有些事件在很长一段时间内观察实际上是不可能的。例如,在一项关于胰腺癌的研究中,胰腺癌是最致命、增长最快的癌症之一;研究人员可能会得到一个非常低的生存时间中位数,这可能表明一半的参与者在三个月内死亡。这些研究也许不会在达到3个月或6个月的时候就停止,可能会持续到5年,但只是在极小的数量上,如果有的话,参与者。生存分析中的事件本质上通常是有害的。死亡是分析的典型事件,通常被称为失败。其他事件,如疾病的发生,复发,恢复吸烟和饮酒,疾病的并发症,也可能是研究的兴趣。生存分析方法不仅可以用于医学领域,还可以用于经济学、政治学、社会学、工程学等领域。
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Choosing statistical tests for survival analysis
Survival analysis is a very specific type of statistical analyses. Survival analysis is aimed to analyze not the event itself but the time lapsed to the event. This time of interest is also referred to as the failure time or survival time. The time used in survival analysis might be measured in different intervals: days, months, weeks, years, etc. The lengthy studies as a matter of course are preferred for being analyzed since they provide stronger evidence and more reliable results. However, it is practically unfeasible for some of the events to be observed over a long period of time. For example, in a study of the pancreatic cancer, one of the most lethal and rapidly growing type of cancer; researchers might get a very low median for survival time, which may indicate that half of the participants died within just a three month period. The studies, perhaps, would not be stopped at the moment of reaching three or six month period and may continue up until five years, but just on the miniscule, if any, number, of participants. The events in the survival analysis are usually deleterious in nature. The death is the prototypical event for the analysis, termed usually as a failure. Other events, such as an occurrence of a disease, relapse, smoking and drinking resumption, complication of the disease, might be of the research interest as well. The survival analysis methods can be used in other than medicine fields as well: in economics, political science, sociology, engineering.
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