母亲噪声暴露对死产风险和氧化应激诱导的后代神经行为改变的影响

IF 2.6 3区 工程技术 Q2 MECHANICS Journal of Thermal Stresses Pub Date : 2023-07-12 DOI:10.3390/stresses3030037
Archana Arjunan, Dhiraj Kumar Sah, Ravindran Rajan
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引用次数: 0

摘要

生命不是从出生开始,而是从受孕开始。胚胎发育是一个特别困难的时期,遗传和环境因素可能相互作用,导致风险。在子宫内和新生儿早期暴露于母亲压力与精神疾病有关,其潜在机制目前正在阐明。本研究探讨了母亲噪声暴露引起的氧化应激诱导的认知神经行为改变与后代自闭症谱系障碍(ASD)之间的新关系。将妊娠期Wistar白化大鼠暴露于噪声(100 dBA/4 h)下,将妊娠期暴露于噪声的妊娠大鼠分为三组和对照组:妊娠早期应激(EGS),发生于妊娠第1 ~ 10天;妊娠后期应激(LGS),发生在第11天至分娩日之间;以及发生在整个妊娠期的足月妊娠应激(FGS)。分析了母鼠应激对子代的影响。本研究发现,噪声暴露在母亲产前成为一种社会心理压力源。在EGS组和LGS组中,雌性大鼠在噪声暴露期间出现持续的中期流产和死胎。噪声暴露组在认知、强迫行为、恐惧和焦虑方面表现出显著变化。噪声暴露组皮质酮和氧化应激标志物升高,抗氧化水平显著降低。因此,母亲的噪音暴露导致反复流产和死产,增加氧化应激,并损害后代的神经发育。
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Impacts of Maternal Noise Exposure on Risk of Stillbirth and Oxidative Stress-Induced Neurobehavioral Changes in Offspring
Life does not start at birth but at conception. Embryonic development is a particularly difficult period in which genetic and environmental factors can interact to contribute to risk. In utero and early neonatal exposure to maternal stress are linked with psychiatric disorders, and the underlying mechanisms are currently being elucidated. This study examined novel relationships between maternal noise exposure causing oxidative-stress-induced neurobehavioral changes in cognition and autism spectrum disorder (ASD) in offspring. Pregnant Wistar albino rats were exposed to noise (100 dBA/4 h). There were three groups of pregnant rats exposed to noise during gestation, as well as a control group: early gestational stress (EGS), which occurs between the 1st and 10th days of pregnancy; late gestational stress (LGS), which occurs between the 11th day and the delivery day; and full-term gestational stress (FGS), which occurs during the entire pregnancy period. Maternal stress effects on the offspring were analyzed. This study observed that noise exposure becomes a psychosocial stressor in the prenatal period of motherhood. In the EGS and LGS groups, female rats showed continuous midterm abortion and stillbirth during noise exposure. The noise-exposed group exhibited significant changes in cognition, obsessive–compulsive behavior, fear, and anxiety. Corticosterone and oxidative stress markers increased, and the antioxidant level was significantly decreased in the noise-exposed group. Therefore, maternal noise exposure causes recurrent abortions and stillbirths, increases oxidative stress, and impairs the offspring’s neurodevelopment.
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来源期刊
Journal of Thermal Stresses
Journal of Thermal Stresses 工程技术-力学
CiteScore
5.20
自引率
7.10%
发文量
58
审稿时长
3 months
期刊介绍: The first international journal devoted exclusively to the subject, Journal of Thermal Stresses publishes refereed articles on the theoretical and industrial applications of thermal stresses. Intended as a forum for those engaged in analytic as well as experimental research, this monthly journal includes papers on mathematical and practical applications. Emphasis is placed on new developments in thermoelasticity, thermoplasticity, and theory and applications of thermal stresses. Papers on experimental methods and on numerical methods, including finite element methods, are also published.
期刊最新文献
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