蚕丝膜对全层皮肤创面表皮恢复的促进作用。

A. Sugihara, K. Sugiura, H. Morita, T. Ninagawa, K. Tubouchi, R. Tobe, M. Izumiya, T. Horio, N. Abraham, S. Ikehara
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引用次数: 161

摘要

我们研究了透明丝素膜(蚕丝膜)对全层皮肤创面的影响。在CRJ:CD-1 nu/nu (ICR nu/nu)小鼠背壁制备全层皮肤切开术(15 mm × 9 mm)。术后14天,丝膜覆盖创面面积减少至创面面积的10%,术后21天创面覆盖再生表皮。相比之下,使用传统的水胶体敷料(Duro Active)敷料的创面在皮切术后14天恢复和表皮再生较少。此外,皮肤切开后21天仅获得部分不完整的表皮生长。最重要的是,与多活性敷料相比,丝膜敷料的愈合时间缩短了7 d。丝质薄膜表现出与冻干猪真皮(Alloask D)几乎相似或稍好一些的促进作用,冻干猪真皮被用作烧伤、溃疡和脱尿炎的敷料。组织学结果显示,与十二指肠活性敷料相比,丝膜敷料的创面胶原再生明显增加,炎症反应和中性粒细胞淋巴细胞浸润减少。结果表明,覆盖蚕丝膜的创面表皮和真皮的再生速度明显快于多活性敷料。最后,丝膜很容易获得,可消毒,透明,它可以很容易地观察组织恢复。因此,与其他敷料相比,丝膜具有优势,可能在临床上对伤口治疗有用。
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Promotive effects of a silk film on epidermal recovery from full-thickness skin wounds.
We examined the effects of the transparent fibroin film (silk film) on full-thickness skin wounds. Full-thickness dermatotomies (15 mm x 9 mm) were prepared on the dorsal wall of CRJ:CD-1 nu/nu (ICR nu/nu) mice. The area of the wounds dressed with silk film was reduced to 10% of that made by the dermatotomy 14 days after the dermatotomy and were covered with regenerated epidermis 21 days after the dermatotomy. In contrast, less recovery and epidermal regeneration were found 14 days after dermatotomy in the wounds dressed with a conventional hydrocolloid dressing (Duro Active). Furthermore, only partial incomplete epidemal growth was obtained 21 days after dermatotomy. Most importantly, the healing time of wounds dressed with silk film was 7 days shorter than those dressed with DuoActive dressing. The silk film showed an almost similar or slightly better promotive effect as the lyophilized porcine dermis (Alloask D), which is used as a dressing for burns, ulcers, and decubitis. Histologic findings revealed that there was greater collagen regeneration and less inflammation and neutrophil-lymphocyte infiltration of the wounds dressed with silk film than with DuoActive dressing. It is clear that regeneration of the epidermis and dermis of the wound beds covered with silk film was faster than with DuoActive dressing. Finally, silk film is easily obtainable, sterilizable, and transparent, and it allows easy observation of tissue recovery. Therefore, silk film offers advantages over other dressings and may be clinically useful for wound treatment.
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