维生素C预处理对小鼠镍致急性肾毒性有保护作用

Imededdine Kadi, F. Dahdouh
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引用次数: 16

摘要

摘要镍是一种丰富的致癌和肾毒性金属,其活性可导致肾脏损害。先前的研究表明,同时服用维生素C对急性和慢性镍中毒有保护作用。然而,关于维生素C预处理在预防镍引起的急性肾毒性中的作用的研究很少。因此,本研究旨在探讨维生素C (VC)预处理对镍急性肾毒性的预防作用。小鼠连续7天口服维生素C (16.6 mg kg-1体重,体重),然后腹腔注射不同剂量的氯化镍(3、5和10 mg Ni kg-1体重),暴露时间为24小时。随后处死动物,取肾脏组织和血液标本进行组织学检查和生化标志物分析。单独的维生素C预处理不会改变血清肾标志物(肌酐、尿素和尿酸)的水平。然而,与对照组相比,单独使用镍治疗显示血清肌酐、尿素和尿酸水平显著增加,肾切片有明显的坏死上皮细胞和炎症细胞浸润。用维生素C预处理和用所有剂量的镍治疗24小时的试验显示,血清肌酐、尿素和尿酸水平显著降低,与先前单独用镍治疗的组相比,组织学变化也有所改善。由此可见,维生素C预处理能有效改善镍致肾组织损伤。
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Vitamin C pretreatment protects from nickel-induced acute nephrotoxicity in mice
Abstract Nickel is an abundant carcinogenic and nephrotoxic metal whose activity leads to renal impairment. Previous studies have shown a protective effect of simultaneous vitamin C administration on acute and chronic nickel toxicity. However, very little research relating to the effect of vitamin C pretreatment in preventing nickel-induced acute nephrotoxicity is available. Therefore, the present study aimed to determine the efficiency of vitamin C (VC) pretreatment in preventing acute renal toxicity of nickel. Mice were pretreated orally with vitamin C (16.6 mg kg-1 body weight, b.w.) for seven consecutive days, prior to intraperitoneal (i.p.) administration of nickel chloride at different doses (3, 5, and 10 mg Ni kg-1 b.w.) for an exposure period of 24 hours. Thereafter, animals were killed and kidney tissue and blood samples were taken for histological examination and biochemical marker analyses. Vitamin C pretreatment alone did not alter the levels of serum kidney markers (creatinine, urea, and uric acid). However, treatment with Ni alone showed a significant increase in the levels of serum creatinine, urea, and uric acid with marked necrotic epithelial cells and infiltration by inflammatory cells in kidney sections as compared to the control group. Pretreatment with vitamin C and treatment with Ni at all doses tested for 24 hours showed a significant decrease in the levels of serum creatinine, urea, and uric acid, as well as an improvement in histological changes compared to those previously seen in the group treated with Ni alone. It is concluded that vitamin C pretreatment effectively improved renal function and tissue damage caused by nickel.
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