系统性红斑狼疮的皮肤表现

D. Panikkath, V. Sandhu
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引用次数: 2

摘要

由免疫介导机制驱动的炎症可导致各种各样的皮肤表现。例如,皮肤性红斑狼疮(CLE)是一种自身免疫性结缔组织疾病,可能局限于皮肤,也可能是系统性红斑狼疮广泛累及多器官的一部分。临床表现分为狼疮特异性(急性、亚急性和慢性)和非特异性皮肤病变。CLE的诊断需要彻底的体格检查,在某些情况下,需要皮肤活检和实验室评估是否有潜在的全身累及。CLE的治疗取决于皮肤表现和疾病的严重程度。除了生活方式方面的措施,特别是避免阳光照射,局部和全身治疗已被证明是有益的。预后因疾病严重程度而异,尽管慢性CLE众所周知会导致外观损害。CLE的早期识别和处理是重要的,因为它也可能是系统性红斑狼疮的表现。患者护理包括教育和与初级保健提供者、皮肤科医生和风湿病学家的密切合作。
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Cutaneous Manifestations of Systemic Lupus Erythematosus
ABSTRACT Inflammation driven by immune-mediated mechanisms can lead to a wide variety of skin manifestations. Cutaneous lupus erythematosus (CLE), for example, is an autoimmune connective tissue disease that may be limited to the skin or be part of the widespread multiorgan involvement seen in systemic lupus erythematosus. Clinical findings are divided into lupus-specific (acute, subacute, and chronic) and nonspecific skin lesions. The diagnosis of CLE requires a thorough physical examination and, in some cases, skin biopsy and laboratory evaluation for any underlying systemic involvement. CLE treatment is dependent on the cutaneous manifestations and severity of disease. In addition to lifestyle measures, particularly avoidance of sunlight, topical and systemic therapies have proven beneficial. Prognosis is varied by disease severity, although chronic CLE notoriously results in cosmetic damage. Early recognition and management of CLE is important as it may also be the presenting manifestation of systemic lupus erythematosus. Patient care includes education and close collaboration with primary care providers, dermatologists, and rheumatologists.
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来源期刊
CiteScore
0.30
自引率
25.00%
发文量
45
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