Protein and peptide drug delivery system: A brief review

The protein and Peptide delivery system is the Novel drug Delivery System. Proteins and peptides are the most abundant components of living cells. There are those that act as enzymes, hormones, structural element and immunoglobulin. Twenty different naturally occurring amino acids combine with each other through peptide bonds and form polymers targeting peptides and proteins. Although the difference between peptides and proteins in peptide contains less than 20 amino acids, they have a molecular weight of less than 5000, while the protein has 50 amino acids or more and its molecular weight is above this value. Most pharmaceutical proteins and peptides are absorbed by IM, IV and the Subcutaneous route of Absorption, but the oral route is better absorbed by protein compared to another. Various problems associated with protein and peptide drug administration are needed to overcome various drug regimens. A few ways available to increase pharmacokinetic and pharmacodynamics properties are chemical modification, construction vehicles, mucoadhesive polymeric system, use of enzyme inhibitors, absorption enhancers, infiltration enhancers etc. Current review defines structure, protein separation, need, benefits, protein function and peptide drug delivery system.