心房扑动住院患者三年生存率的预测因素

A. Aker, U. Chernyaha-Royko, M. Sorokivskyy, I. Tumak, Y. Ivaniv, O. Zharinov
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摘要

目的是评估心房扑动患者在三年随访期间住院后的生存分析,并确定生存的独立预测因素。材料和方法。这项单中心前瞻性研究纳入126例不同形式AFL患者,其中男性86例(68.3%),女性40例(31.7%),中位年龄为65.5岁(四分位数为55-73)。中位随访时间为指数住院后26个月(四分位数1-46)。对连续变量采用Cox回归进行生存分析,对排序变量(超过2个秩)采用Kaplan - Meier曲线估计和χ2统计,对二元变量采用Cox 's f检验。在3年随访期间,22例(17.5%)患者死亡。36个月累计生存率为80.9%。多因素Cox回归分析显示,左室射血分数降低、左室壁肥厚、AFL既往发作、AFL期间血流动力学不稳定和慢性肾脏疾病是与死亡相关的重要危险因素(p<0.05)。36个月的累计生存率为80.9%。生存不良的独立预测因子为左室射血分数降低、左室壁肥厚、AFL既往发作、AFL期间血流动力学不稳定、慢性肾脏疾病。
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Predictors of three-year survival in hospitalized patients with atrial flutter
The aim – to estimate the survival analysis of patients with atrial flutter after index hospitalization during a three-year follow-up and to determine independent predictors of survival.Materials and methods. The one-center prospective study included 126 patients with various forms of AFL, among them 86 (68.3 %) men and 40 (31.7 %) women, the median age was 65.5 (quartiles 55–73) years. The median follow-up was 26 (quartiles 1–46) months after index hospitalization. Survival analysis was performed by Cox regression for continuous variables, also by estimating Kaplan – Meier curves and by χ2 for ranked variables (with more than 2 ranks) and using Cox’s F-test for binary variables.Results. During the three-year follow-up period 22 (17.5 %) patients died. The 36-months cumulative survival rate was 80.9 %. In multivariate Cox regression analysis presence of decreased left ventricular ejection fraction, left ventricular wall hypertrophy, previous episodes of AFL, hemodynamic instability during AFL and chronic kidney disease (p<0.05) were significant risk factors associated with mortality.Conclusion. The cumulative survival rate at 36 months of follow-up was 80.9 %. Independent predictors of poor survival are decreased left ventricular ejection fraction, left ventricular wall hypertrophy, presence of previous episodes of AFL, hemodynamic instability during AFL, chronic kidney disease.
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