急性淋巴母细胞和髓性白血病患者HLA等位基因的频率

Rasime Derya Güleç, F. Arslan
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引用次数: 0

摘要

目的:我们的目的是研究人类白细胞抗原(HLA) -特别是HLA- a、HLA- b、HLA- c、HLA- drb1和HLA- dqb1基因-与急性淋巴细胞白血病(ALL)和急性髓性白血病(AML)患者之间的潜在相关性。材料和方法:我们对393名ALL患者、431名AML患者和564名健康供者组成的对照组进行了HLA等位基因频率分析。此外,我们还探讨了小儿和成人ALL患者HLA等位基因分布的差异。结果:与供体组相比,AML患者HLA-A*32抗原频率增高(p=0.015, OR: 1.682)。相反,ALL患者HLA-B*55 (p=0.027, OR: 0.545)、AML患者HLA-B*14 (p=0.023, OR: 0.397)、AML患者HLA-B*55 (p=0.04, OR: 0.604)的频率显著降低。值得注意的是,患者和对照组在HLA II类等位基因频率和分析上没有明显差异。此外,儿童(n=165)和成人(n=228) ALL患者HLA-A*25 (p=0.019, OR: 8.426)和DRB1*04 (p=0.049, OR: 1.491)的频率存在显著差异。结论:HLA-A*32可能是AML的遗传易感因素,HLA-A*25和DRB1*04可能是儿科ALL患者的潜在遗传危险因素。相反,HLA-B*55似乎是对抗两种形式的急性白血病的潜在保护因子。
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Frequencies of HLA Alleles in Patients with Acute Lymphoblastic and Myeloid Leukemia
Objective: Our objective was to investigate the potential correlation between human leukocyte antigens (HLA) - specifically, HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 genes - and patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Material and Methods: We conducted an analysis of HLA allele frequencies among 393 patients with ALL, 431 patients with AML, and a control group comprising 564 healthy donors. Additionally, we explored the variation in HLA allele distribution between pediatric and adult patients diagnosed with ALL. Results: In comparison to the donor group, a heightened frequency of HLA-A*32 antigen was observed in AML patients (p=0.015, OR: 1.682). Conversely, the frequencies of HLA-B*55 (p=0.027, OR: 0.545) in ALL patients, HLA-B*14 (p=0.023, OR: 0.397), and HLA-B*55 (p=0.04, OR: 0.604) in AML patients were notably diminished. Notably, there were no discernible differences in HLA Class II allele frequency and analysis between the patient and control groups. Moreover, a significant distinction in the frequencies of HLA-A*25 (p=0.019, OR: 8.426) and DRB1*04 (p=0.049, OR: 1.491) was identified between pediatric patients (n=165) and adult patients (n=228) with ALL. Conclusion: The findings indicate that HLA-A*32 might serve as a genetic predisposing factor for AML, and HLA-A*25 and DRB1*04 could be potential genetic risk factors for pediatric ALL patients. Conversely, HLA-B*55 appears to be a potential protective factor against both forms of acute leukemia.
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