在临床惰性时代实现缓解:是什么阻碍了我们治疗2型糖尿病?

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Diabetology Pub Date : 2023-02-24 DOI:10.3390/diabetology4010011
A. Suits, Ridhi R. Gudoor, J. Shubrook
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引用次数: 0

摘要

尽管治疗方案的发展和对病理生理学的理解的提高,2型糖尿病的治疗仍然不令人满意。目前的管理指南因临床惯性而复杂化,导致超过一半的患者未能达到血糖目标。专家共识已经定义了糖尿病缓解状态,通过治疗可以诱导血糖水平持续正常化。有证据表明,代谢手术、强化生活方式改变和药物治疗方法都是在病程早期实现缓解的可行选择。作者回顾了这些策略,并包括实际考虑,以帮助追求缓解。
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Achieving Remission in the Era of Clinical Inertia: What Is Preventing Us from Treating Type 2 Diabetes?
Despite evolution in treatment options and improved understanding of pathophysiology, the treatment of type 2 diabetes remains unsatisfactory. Current management guidelines complicated by clinical inertia have resulted in over half of patients failing to meet glycemic targets. Expert consensus has defined a state of diabetes remission whereby treatment can induce sustained normalization of glucose levels. Evidence suggests that metabolic surgery, intensive lifestyle modification, and pharmacologic approaches are each viable options for achieving remission when implemented early in the disease course. The authors review each of these strategies and include practical considerations to aid in the pursuit of remission.
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