Efficacy of Afoxolaner in Six Cases of Canine Demodicosis

The efficacy of afoxolaner for canine demodicosis was evaluated in six cases (generalized type: five cases, localized type: one case) of Demodex canis infestation. Afoxolaner was administered orally at the doses of 2.7–5.6 mg/kg of body weight on day 0 and at 3 to 6 week intervals. The administration frequency of afoxolaner required for the disappearance of mites was one time in two cases, two times in three cases, and three times in one case. Cutaneous lesions took 4–12 weeks to heal after initial treatment in all cases. No adverse reactions were recorded in the follow-up with owners, or were found in the physical examination at the reexamination visit during treatment with afoxolaner. In addition, no clinical recurrence was observed in any case in the 6 months in all cases after the final medical examination. On the basis of these results, afoxolaner is effective for the treatment of canine demodicosis.