含喹啉核杂环化合物的抗菌筛选

International Letters of Chemistry, Physics and Astronomy Pub Date : 2017-10-01 DOI:10.18052/WWW.SCIPRESS.COM/ILCPA.76.27

S. Baluja, N. Godvani, S. Chanda

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摘要

本文利用Vilsmeier-Haack试剂合成了一些新的氰吡啶和异恶唑衍生物，并通过FTIR、1H NMR和质谱等方法对其结构进行了确证。用琼脂孔扩散法在DMSO和DMF中对革兰氏阳性和革兰氏阴性细菌的抑菌活性进行了研究。观察到活性取决于三个S:溶剂、应变和结构。

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Antibacterial Screening of some Heterocyclic Compounds Containing Quinoline Nucleus

In this work, some novel derivatives of Cyanopyridines and Isoxazoles were synthesized using Vilsmeier-Haack reagent and their structures were confirmed by FTIR, 1H NMR and mass spectroscopic methods. The antibacterial activities of these synthesized compounds were studied in DMSO and DMF by agar well diffusion method against some Gram positive and Gram negative bacteria. It is observed that activity depends upon three S: solvent, strain and structure.

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International Letters of Chemistry, Physics and Astronomy

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