蛋白酶抑制剂(PIs):抗坏死性营养物质作物保护制剂的候选分子。

IF 1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Protein and Peptide Letters Pub Date : 2023-01-01 DOI:10.2174/0929866530666221124123905
R Aswati Nair, Padmesh Pillai, Sharmila Raj
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引用次数: 1

摘要

坏死性植物病原体对几种作物的生产力构成了严重的挑战,造成幼苗损害,出苗期前和出苗期后的潮湿和根腐病,从而降低了植物的生长和产量。众所周知,它们通过分泌多种水解酶来获取营养,从而引起寄主植物组织的广泛浸渍。在各种水解酶中,蛋白酶在营养的坏死性模式中起着关键作用,从而决定了致病力。寄主植物通常通过蛋白质(多肽),特别是通过蛋白酶抑制剂(pi)来抵消坏死性蛋白质水解事件。PIs作为抗代谢蛋白抑制植物病原性分泌蛋白酶的活性,在宿主先天免疫功能中发挥重要作用。它们在植物储存器官中的丰富程度解释了它们的抗营养相互作用,从而阻止了病原体的入侵。因此,pi构成了潜在的候选物,可以作为有效的抗菌剂部署在农业中,特别是针对坏死性土壤传播病原体。本文综述了植物中pi分子的鉴定及其对坏死性植物病原体的抑制作用,并探讨了利用这些分子作为有效的抗坏死性植物病原体进行疾病管理的前景。
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Protease Inhibitors (PIs): Candidate Molecules for Crop Protection Formulations against Necrotrophs.

Necrotrophic phytopathogens pose a serious challenge to the productivity of several crops causing seedling damage, pre- and post-emergence damping-off and root rot thus reducing plant growth and yield. They are known to gain nutrition by secreting a diverse array of hydrolytic enzymes and thereby causing extensive host plant tissue maceration. Amongst the diverse hydrolases, proteases play a pivotal role in the necrotrophic mode of nutrition and thereby in determining pathogenic virulence. Host plants often counteract the necrotrophic proteolysis events by proteins (peptides), particularly through protease inhibitors (PIs). PIs play an important role in host innate immunity function by functioning as anti-metabolic proteins inhibiting the activity of phytopathogenic secretory proteases. Their abundance in plant storage organs explains their anti-nutritional interaction which stalls pathogenic invasion. PIs, therefore, constitute potential candidates that can be deployed as effective antimicrobials in agriculture, particularly against necrotrophic soil-borne pathogens. The present review traces the progress made in the identification of PIs from plants, and their inhibitory potential against necrotrophic phytopathogens and explores prospects of utilizing these molecules as effective anti-necrotrophic formulations for disease management.

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来源期刊
Protein and Peptide Letters
Protein and Peptide Letters 生物-生化与分子生物学
CiteScore
2.90
自引率
0.00%
发文量
98
审稿时长
2 months
期刊介绍: Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis
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