Actin cytoskeleton-modulating T3SS2 effectors and their contribution to the Vibrio parahaemolyticus-induced diarrhea.

To understand how bacterial pathogens cause diseases is the most important step in order to prevent the infection and develop an effective treatment. However, the past proceeding studies make us aware of quite-complicated interactions between the host and pathogenic bacteria. Vibrio parahaemolyticus, a food-born pathogen that is a subject of our study, causes inflammatory diarrhea in human upon ingestion of contaminated raw or undercooked seafood. Many virulence factors has been proposed since its discovery in Osaka around 70 years ago, while our research group has revealed that one of these virulence factors, type 3 secretion system 2 (T3SS2), is necessary for diarrhea induced by this bacterium. In addition, we recently found two novel T3SS2 effectors (VopO and VopV) that manipulate the actin cytoskeleton in infected host cells. In this article, I would like to show our findings with regard to biological activities of the effectors and their contributions to the T3SS2-induced enterotoxicity.