伊拉克老年人疗养院中可能不适当的药物:药剂师基于2019年啤酒标准的评估和干预

Hussein Naqash
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摘要

随着人类预期寿命的延长,世界范围内老年人的数量正在增长;在伊拉克,2019年65岁以上老年人的数量估计为134万。老年人使用潜在不适当药物(PIMs)的比例很高,这与药物不良反应的风险增加有关。本研究基于2019 Beers标准、标准的应用和药剂师的干预,调查了伊拉克老年养老院(NH)居民对pim的使用情况。2019年1月至2019年4月,在伊拉克巴格达的2个NHs进行了一项介入性研究。共纳入109例年龄≥65岁、每日用药≥1种的NH居民。在评估完成前出院的患者被排除在外。有PIMs的患者使用的药物(5.7±3.2)明显多于无PIMs的患者(2.0±1.46)(p<0.0001)。根据2019年Beers标准确定的pim总数为163个;其中140例(85.9%),药剂师建议更改处方,112例(68.7%)停止或更改处方,医生接受率为80%。我们的结果表明,使用pim治疗伊拉克NH居民与多药有关。因此,在伊拉克,药剂师应该对有多种药物或多种并发诊断的老年人的处方进行pim审查,以减少不良事件的风险。
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Potentially inappropriate medications in nursing homes of iraqi elders: Pharmacists’ assessment and intervention based on 2019 beers criteria
The number of elderly people worldwide is growing with the increasing life expectancy of the human population; in Iraq, the number of elderly people aged ≥65 years was estimated to be 1.34 million in 2019. The use of potentially inappropriate medications (PIMs) is high among older adults, which is associated with an increased risk of adverse drug reactions. This study investigated the use of PIMs among elderly nursing home (NH) residents in Iraq based on 2019 Beers criteria and the application of the criteria and intervention by pharmacists. An interventional study was conducted from January 2019 to April 2019 at 2 NHs in Baghdad, Iraq. A total of 109 NH residents aged ≥65 years that were using ≥1 daily medicine were included. Patients discharged before completion of the assessment were excluded. Patients with PIMs were using significantly more medications (5.7±3.2) than those without PIMs (2.0 ±1.46) (p<0.0001). The total number of PIMs identified according to the 2019 Beers criteria was 163; for 140 of these (85.9%), pharmacists recommended changing the prescription, with 112 (68.7%) discontinued/changed as a result for an acceptance rate of 80% by physicians. Our results indicate that the use of PIMs for the treatment of Iraqi NH residents is associated with polypharmacy. Thus, prescriptions for elderly people in Iraq with polypharmacy or multiple concurrent diagnoses should be reviewed for PIMs by pharmacists to reduce the risk of adverse events.
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