Ivana Karlova Zubata, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Jan Novak
{"title":"移植前粘膜相关不变性 T 细胞（MAIT）计数高，预示着骨髓再生障碍的病程有利。","authors":"Ivana Karlova Zubata, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Jan Novak","doi":"10.5507/bp.2023.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues. Previous works suggested that MAIT cells survive exposure to cytotoxic drugs in these locations. We sought to determine if they maintain their anti-infective functions after myeloablative chemotherapy.</p><p><strong>Methods: </strong>We correlated the amount of MAIT cells (measured by flow cytometry) in the peripheral blood of 100 adult patients before the start of myeloablative conditioning plus autologous stem cell transplantation with the clinical and laboratory outcomes of aplasia.</p><p><strong>Results: </strong>The amount of MAIT cells negatively correlated with peak C-reactive protein level and the amount of red blood cell transfusion units resulting in earlier discharge of patients with the highest amount of MAIT cells.</p><p><strong>Conclusion: </strong>This work suggests the anti-infectious potential of MAIT cells is maintained during myeloid aplasia.</p>","PeriodicalId":55363,"journal":{"name":"Biomedical Papers-Olomouc","volume":" ","pages":"139-146"},"PeriodicalIF":0.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia.\",\"authors\":\"Ivana Karlova Zubata, Jitka Smetanova Brozova, Tomas Karel, Barbora Bacova, Jan Novak\",\"doi\":\"10.5507/bp.2023.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues. Previous works suggested that MAIT cells survive exposure to cytotoxic drugs in these locations. We sought to determine if they maintain their anti-infective functions after myeloablative chemotherapy.</p><p><strong>Methods: </strong>We correlated the amount of MAIT cells (measured by flow cytometry) in the peripheral blood of 100 adult patients before the start of myeloablative conditioning plus autologous stem cell transplantation with the clinical and laboratory outcomes of aplasia.</p><p><strong>Results: </strong>The amount of MAIT cells negatively correlated with peak C-reactive protein level and the amount of red blood cell transfusion units resulting in earlier discharge of patients with the highest amount of MAIT cells.</p><p><strong>Conclusion: </strong>This work suggests the anti-infectious potential of MAIT cells is maintained during myeloid aplasia.</p>\",\"PeriodicalId\":55363,\"journal\":{\"name\":\"Biomedical Papers-Olomouc\",\"volume\":\" \",\"pages\":\"139-146\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Papers-Olomouc\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5507/bp.2023.011\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/3/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Papers-Olomouc","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5507/bp.2023.011","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/3/10 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
目的：粘膜相关不变性 T 细胞（MAIT）是具有抗感染潜能的非常规 T 细胞。MAIT 细胞能检测并对抗粘膜表面和外周组织中的微生物。以前的研究表明，MAIT 细胞在这些部位暴露于细胞毒性药物后仍能存活。我们试图确定 MAIT 细胞在髓鞘脱落化疗后是否仍能保持其抗感染功能：方法：我们将100名成年患者在开始进行髓脱落调理加自体干细胞移植前外周血中MAIT细胞的数量（通过流式细胞术测量）与再生障碍的临床和实验室结果进行了相关分析：结果：MAIT细胞的数量与C反应蛋白峰值水平和红细胞输血单位数量呈负相关，导致MAIT细胞数量最多的患者提前出院：结论：这项研究表明，MAIT细胞的抗感染潜能在骨髓增生过程中得以保持。
High pre-transplant Mucosal Associated Invariant T Cell (MAIT) count predicts favorable course of myeloid aplasia.
Aims: Mucosal Associated Invariant T (MAIT) cells are unconventional T cells with anti-infective potential. MAIT cells detect and fight against microbes on mucosal surfaces and in peripheral tissues. Previous works suggested that MAIT cells survive exposure to cytotoxic drugs in these locations. We sought to determine if they maintain their anti-infective functions after myeloablative chemotherapy.
Methods: We correlated the amount of MAIT cells (measured by flow cytometry) in the peripheral blood of 100 adult patients before the start of myeloablative conditioning plus autologous stem cell transplantation with the clinical and laboratory outcomes of aplasia.
Results: The amount of MAIT cells negatively correlated with peak C-reactive protein level and the amount of red blood cell transfusion units resulting in earlier discharge of patients with the highest amount of MAIT cells.
Conclusion: This work suggests the anti-infectious potential of MAIT cells is maintained during myeloid aplasia.
期刊介绍：
Biomedical Papers is a journal of Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic. It includes reviews and original articles reporting on basic and clinical research in medicine.
Biomedical Papers is published as one volume per year in four issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
