NOS3 (rs2070744)和GNB3 (rs5443)基因多态性在高血压患者内皮功能障碍通路和颈动脉内膜-中膜厚度中的作用

IF 1.3 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY General physiology and biophysics Pub Date : 2023-03-01 DOI:10.4149/gpb_2022060
Andrii Sydorchuk, Larysa Sydorchuk, Adelina Gutnitska, Valentina Vasyuk, Oleksii Tkachuk, Valentina Dzhuryak, Yuriy Myshkovskii, Petro Kyfiak, Ruslan Sydorchuk, Oksana Iftoda
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引用次数: 1

摘要

调控一氧化氮和内皮源性收缩因子之间平衡的机制,以及高血压患者内皮功能障碍的遗传易感性仍有待确定。通过100例高血压患者的病例对照研究,阐明NOS3 (rs2070744)和GNB3 (rs5443)基因多态性对内皮功能障碍和颈动脉“中内膜”厚度(IMT)变化的影响。结果发现,NOS3基因С-allele的存在显著增加颈动脉粥样硬化斑块的发生风险(OR95%CI: 1.24-11.20;NOS3基因低表达概率(OR95%CI: 17.72 ~ 520.0;< 0.001)。纯合子携带С-allele GNB3基因具有保护作用,颈动脉IMT增加、动脉粥样硬化斑块形成和sVCAM-1升高的几率最低(OR = 0.10-0.34;OR95%CI: 0.03 - -0.95;r≤0.035-0.001)。反之,Т-allele的GNB3基因显著增加颈动脉IMT增加的风险(OR95%CI: 1.09-7.74;(r = 0.027),包括动脉粥样硬化斑块的发展,GNB3 (rs5443)与心血管病理相关。
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The role of NOS3 (rs2070744) and GNB3 (rs5443) genes' polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients.

The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, and genetic predisposition to endothelial dysfunction in hypertensive patients remain to be determined. One-hundred hypertensive patients participated in the case-control study to clarify the risk of endothelial dysfunction and carotid "intima media" thickness (IMT) changes depending on NOS3 (rs2070744) and GNB3 (rs5443) genes' polymorphisms. It is found that presence of NOS3 gene's С-allele significantly elevates the risk of atherosclerotic plaques on carotid arteries (OR95%CI: 1.24-11.20; р = 0.019) and the probability of low NOS3 gene expression (OR95%CI: 17.72-520.0; р < 0.001). Homozygous carriage of С-allele of GNB3 gene is protective and corresponds to the lowest chances of the carotid IMT increase, atherosclerotic plaques formation and sVCAM-1 elevation (OR = 0.10-0.34; OR95%CI: 0.03-0.95; р ≤ 0.035-0.001). Vice versa, Т-allele of GNB3 gene significantly augments the risk of the carotid IMT increase (OR95%CI: 1.09-7.74; р = 0.027) including development of atherosclerotic plaques, associating GNB3 (rs5443) with cardiovascular pathology.

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来源期刊
General physiology and biophysics
General physiology and biophysics 生物-生化与分子生物学
CiteScore
2.70
自引率
0.00%
发文量
42
审稿时长
6-12 weeks
期刊介绍: General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.
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