奥拉帕尼治疗 BRCA1 基因突变的神经内分泌性前列腺癌后的间质性肺炎：病例报告。

IF 0.5 Q4 ONCOLOGY International Cancer Conference Journal Pub Date : 2023-01-03 eCollection Date: 2023-04-01 DOI:10.1007/s13691-022-00592-5

Masashi Kaitsumaru, Masaki Shiota, Dai Takamatsu, Leandro Blas, Takashi Matsumoto, Junichi Inokuchi, Yoshinao Oda, Masatoshi Eto

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摘要

一名67岁的转移性前列腺癌患者接受了利普瑞林和恩杂鲁胺治疗，但1年后出现了影像学进展。虽然开始了多西他赛化疗，但肝脏出现转移，血清中神经特异性烯醇化酶升高。右腹股沟淋巴结转移的针刺活检病理结果显示为神经内分泌癌。初次诊断时，FoundationOne CDx® 使用前列腺活检样本检测出 BRCA1 基因突变（3-7 内含子缺失），但 BRACAnalysis® 检测显示种系中没有 BRCA 基因突变。随后开始奥拉帕尼治疗，结果肿瘤明显缓解，但合并间质性肺炎。该病例表明，奥拉帕利对 BRCA1 基因突变的神经内分泌型前列腺癌有效，但可能导致间质性肺炎。

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Interstitial pneumonia after regression by olaparib for neuroendocrine prostate cancer with BRCA1 mutation: a case report.

A 67-year-old man with metastatic prostate cancer was treated with leuprorelin and enzalutamide, but presented radiographic progression after 1 year. Although docetaxel chemotherapy was initiated, liver metastasis appeared with elevation of nerve-specific enolase in serum. Pathological findings of needle biopsy of lymph node metastasis in the right inguinal region showed neuroendocrine carcinoma. FoundationOne CDx^® using a biopsy sample of the prostate at initial diagnosis detected the BRCA1 mutation (deletion of intron 3-7), but BRACAnalysis^® test revealed no BRCA mutation in germline. Then, olaparib treatment was initiated, resulting in remarkable remission of tumors, but comorbidity with interstitial pneumonia. This case suggested that olaparib could be effective for neuroendocrine prostate cancer with BRCA1 gene mutation, but may cause interstitial pneumonia.

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)