Optimal Patient Selection and Treatment Timing for Tolvaptan Therapy Following Cardiovascular Surgery.

collecting duct.3 It may be of great interest to investigate other predictors that are associated with the achievement of the primary endpoint in the study of Matsuda et al. The optimal timing to initiate tolvaptan is another concern. Matsuda et al initiated tolvaptan on postoperative Day 2. Earlier initiation of tolvaptan orally or intravenously may have more clinical benefit by increasing urine volume and maintaining renal function.4