I. Monteiro, L. Farias, R. Araujo, Lícia Borges Pontes
{"title":"两性霉素B去氧胆酸酯后并发肾损害的糖尿病患者鼻-眶毛霉病:两性霉素B脂质复合物治疗的作用","authors":"I. Monteiro, L. Farias, R. Araujo, Lícia Borges Pontes","doi":"10.12662/2317-3076JHBS.V9I1.3545.P%P.2021","DOIUrl":null,"url":null,"abstract":"Introduction: Mucormycosis is an infection caused by the ubiquitous saprophyte fungi with rapid and aggressive progression, especially in immunocompromised patients. Case report: A 57-year-old woman diagnosed with rhino-orbital mucormycosis presented with decreased renal function after treatment with amphotericin B deoxycholate which was discontinued. Renal function improved after amphotericin B lipid-complex, being also treated with itraconazole, and otorhinolaryngological surgery. Conclusion: The use of Amphotericin B deoxycholate may result in adverse effects. In this situation, Amphotericin B lipid formulation is usually the drug of choice.","PeriodicalId":16071,"journal":{"name":"Journal of Health & Biological Sciences","volume":"7 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rhino-orbital mucormycosis in a diabetes patient with renal impairment after amphotericin B deoxycholate: the role of amphotericin B lipid-complex treatment\",\"authors\":\"I. Monteiro, L. Farias, R. Araujo, Lícia Borges Pontes\",\"doi\":\"10.12662/2317-3076JHBS.V9I1.3545.P%P.2021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Mucormycosis is an infection caused by the ubiquitous saprophyte fungi with rapid and aggressive progression, especially in immunocompromised patients. Case report: A 57-year-old woman diagnosed with rhino-orbital mucormycosis presented with decreased renal function after treatment with amphotericin B deoxycholate which was discontinued. Renal function improved after amphotericin B lipid-complex, being also treated with itraconazole, and otorhinolaryngological surgery. Conclusion: The use of Amphotericin B deoxycholate may result in adverse effects. In this situation, Amphotericin B lipid formulation is usually the drug of choice.\",\"PeriodicalId\":16071,\"journal\":{\"name\":\"Journal of Health & Biological Sciences\",\"volume\":\"7 1\",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Health & Biological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12662/2317-3076JHBS.V9I1.3545.P%P.2021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Health & Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12662/2317-3076JHBS.V9I1.3545.P%P.2021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rhino-orbital mucormycosis in a diabetes patient with renal impairment after amphotericin B deoxycholate: the role of amphotericin B lipid-complex treatment
Introduction: Mucormycosis is an infection caused by the ubiquitous saprophyte fungi with rapid and aggressive progression, especially in immunocompromised patients. Case report: A 57-year-old woman diagnosed with rhino-orbital mucormycosis presented with decreased renal function after treatment with amphotericin B deoxycholate which was discontinued. Renal function improved after amphotericin B lipid-complex, being also treated with itraconazole, and otorhinolaryngological surgery. Conclusion: The use of Amphotericin B deoxycholate may result in adverse effects. In this situation, Amphotericin B lipid formulation is usually the drug of choice.