肿瘤坏死因子抑制剂和酪氨酸激酶抑制剂在强直性脊柱炎和髓系肿瘤中的同时应用。

IF 1.3 Q4 RHEUMATOLOGY European journal of rheumatology Pub Date : 2022-10-01 DOI:10.5152/eurjrheum.2022.21097
Akash Gupta, Yuliya Afinogenova, Nikolai A Podoltsev, Abhijeet Danve
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引用次数: 0

摘要

生物疾病调节剂(bDMARDs)在控制自身免疫性风湿病症状方面非常有效。癌症诊断后是否继续使用bdmard对患者和医生来说都是一个挑战。在这里,我们描述了一个中年男性强直性脊柱炎的病例,他被控制在英夫利昔单抗(IFX),发现有一个髓系肿瘤与血小板衍生生长因子受体β重排。患者开始使用酪氨酸激酶抑制剂伊马替尼。鉴于其对患者生活质量的显著积极影响,IFX继续治疗并取得了良好的结果。本病例强调了在适当的血液恶性肿瘤病例中,在平衡免疫抑制剂的风险和益处方面共同决策的重要性。
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Concurrent use of tumor necrosis factor inhibitor and tyrosine kinase inhibitor in ankylosing spondylitis and myeloid neoplasm.

Biologic disease-modifying agents (bDMARDs) are highly effective in controlling the symptoms of autoimmune rheumatic diseases. The decision on whether to continue bDMARDs following a cancer diagnosis can be challenging for patients and physicians. Here, we describe a case of a middle-aged male with ankylosing spondylitis who was controlled on infliximab (IFX) and found to have a myeloid neoplasm with Platelet-Derived Growth Factor Receptor Beta rearrangement. The patient was started on a tyrosine kinase inhibitor imatinib. Given its significant positive effect on patient's quality of life, IFX was continued with a favorable outcome. This case highlights the importance of shared decisionmaking in balancing risks and benefits of immunosuppressants in appropriate cases of hematologic malignancy.

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