胰岛异种移植

Q3 Pharmacology, Toxicology and Pharmaceutics Drug Discovery Today: Disease Models Pub Date : 2017-03-01 DOI:10.1016/j.ddmod.2017.11.004

Melanie L. Graham , Henk-Jan Schuurman

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引用次数: 7

摘要

本文就异种胰岛细胞移植的研究现状作一综述。在四个部分中，我们提出(1)简短介绍临床胰岛移植使用来自死者的胰岛，以异种胰岛移植的基本原理结束;(2)糖尿病非人灵长类动物的胰岛存活和功能;(3)与临床发展相关的动物模型特征;(4)该模型在非人灵长类动物中的局限性和翻译价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pancreatic islet xenotransplantation

This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (3) features in this animal model that are relevant for clinical development; and (4) limitations and translational value of the model in nonhuman primates.

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.