辣木减轻白化大鼠铅诱导的免疫毒性

R. Elgawish, H. Abdel-Rahman, S. Helmy, D. I. Kabil, H. Abdelrazek
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引用次数: 1

摘要

本研究旨在评价辣木对铅对雄性大鼠免疫指标的改善作用。28只成年雄性大鼠随机分为4组;对照组给予蒸馏水。用44 mg /kg BW剂量的醋酸铅给药。辣木组以50 mg/ kg BW辣木叶提取物处理。铅和辣木处理组分别给予44 mg/kg醋酸铅和50 mg/kg辣木提取物。采用灌胃管口服治疗,疗程1个月。实验结束时,处死大鼠;除了采集血液和组织样本外,还记录脾脏和胸腺的重量。测定血清中肿瘤坏死因子α (TNF-α)、干扰素γ (IF-γ)、白细胞介素-2 (IL-2)和总抗氧化能力(TAC)。对大鼠进行全血图像评价。与对照组相比,铅和辣木处理的大鼠体重增加明显减少(P<0.05)。与辣木处理组相比,铅和辣木联合给药组脾脏重量显著(P<0.05)增加。与其他组相比,给铅组产生更高的TNF-α、IL-2和IF-γ水平(P<0.001)。相反,经铅处理的大鼠TAC水平显著降低(P<0.001)。铅处理大鼠红细胞明显减少(P<0.01),血红蛋白明显降低(P=0.07)。铅中毒大鼠脾脏白色髓内淋巴滤泡增生,红色髓内含铁血黄素色素增生。注射铅的大鼠胸腺皮质区有明显的增殖。大鼠脾和胸腺对NF-κB和CD8+的免疫反应性明显高于其他各组(P<0.01)。综上所述,辣木提取物可改善铅暴露大鼠的免疫毒性。
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Alleviation of Lead-Induced Immunotoxicity by Moringa oleifera in Albino Rats
The existing study was designed to evaluate the ameliorative influences of Moringa oleifera on several immune parameters in male rats subsequent to lead administration. Twenty eight adult male rats were randomly assigned equally into 4 groups; control group was given distilled water. Lead treated rats were administrated a dose of 44 mg of lead acetate/kg BW. Moringa group was treated with 50 mg/ kg BW of Moringa oleifera leaf extract. Lead and moringa treated group was given a dose of 44 mg/kg of lead acetate and 50 mg/ kg of moringa extract. Treatments were given orally by gavage tube for one month. By the termination of the experimental period, rats were immolated; spleen and thymus weights were recorded in addition to the collection of blood and tissue samples. Tumor necrosis factor alpha (TNF-α), interferon gamma (IF-γ), interlukin-2 (IL-2) and total antioxidant capacity (TAC) were assayed in serum. Complete blood picture was evaluated for rats. Body weight gain was reduced significantly (P<0.05) in lead and moringa treated rats in comparison to control. A significant (P<0.05) increase in spleen weights was observed in lead and moringa co-administered group compared to moringa treated group. Lead administration produced higher (P<0.001) levels of TNF-α, IL-2 and IF-γ compared to that in other groups. In contrary, the level of TAC was significantly (P<0.001) reduced in lead treated rats. A significant (P<0.01) reduction in RBCs and low level of hemoglobin (P=0.07) were observed in lead-treated rats. Spleen of rats receiving lead showed widespread hyperplasia of lymphoid follicles in white pulp and hemosiderin pigment in red pulp. Thymus of rats receiving lead showed marked proliferation in the cortical region. Spleen and thymus of rats receiving lead showed a higher (P<0.01) immune reactivity for NF-κB and CD8+ parallel to that in other groups.  In conclusion, the administration of Moringa oleifera extract ameliorates the immunotoxicity induced by lead exposure in rats.
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