COVID-19黎巴嫩精神分裂症康复患者的认知功能

IF 3.6 3区 医学 Q1 PSYCHIATRY Annals of General Psychiatry Pub Date : 2023-03-11 DOI:10.1186/s12991-023-00435-4
Chadia Haddad, Angela Chamoun, Hala Sacre, Souheil Hallit, Pascale Salameh, Benjamin Calvet
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引用次数: 1

摘要

目前尚不清楚COVID-19(一种由SARS-CoV-2病毒引起的传染病)是否与精神分裂症患者认知功能恶化有关。本研究旨在评估十字精神病院(HPC)精神分裂症患者在COVID-19前后认知功能的变化及其相关因素。方法:对2019年年中至2021年6月在十字精神病院(HPC)随访的95名精神分裂症患者进行了一项前瞻性队列研究。该队列分为诊断为COVID-19的组(n = 71)和未诊断为COVID-19的组(n = 24)。问卷内容包括精神分裂症认知简要评定量表(BACS)、阳性和阴性症状量表(PANSS)、精神分裂症卡尔加里抑郁量表(CDSS)和日常生活活动量表(ADL)。结果:重复测量方差分析显示,时间以及时间与是否诊断COVID-19的交互作用对认知无显著影响。然而,是否被诊断为COVID-19对整体认知功能(p = 0.046)、言语记忆(p = 0.046)和工作记忆(p = 0.047)有显著影响。在基线时被诊断为COVID-19与认知障碍之间的相互作用与较高的认知缺陷显著相关(Beta = 0.81;p = 0.005)。临床症状、自主性、抑郁与认知无相关性(p > 0.05)。结论:COVID-19疾病影响全球认知和记忆,诊断为COVID-19的患者在这些领域的缺陷多于未诊断为COVID-19的患者。需要进一步的研究来阐明COVID-19精神分裂症患者认知功能的变化。
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Cognitive function in recovered COVID-19 Lebanese patients with schizophrenia.

Introduction: It remains unclear whether COVID-19 which is an infectious disease caused by the SARS-CoV-2 virus is associated with the deterioration of cognitive function among patients with schizophrenia. This study aimed to evaluate changes in cognitive function before and after COVID-19 and associated factors among patients with schizophrenia at the Psychiatric Hospital of the Cross (HPC).

Methods: A prospective cohort study was conducted among 95 patients with schizophrenia followed from mid-2019 until June 2021 at the Psychiatric Hospital of the Cross (HPC). This cohort was divided into a group diagnosed with COVID-19 (n = 71) and another not diagnosed with COVID-19 (n = 24). The questionnaire included the Brief Assessment of Cognition in Schizophrenia (BACS), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), and Activities of Daily Living (ADL).

Results: The repeated-measures ANOVA showed no significant effect of time and the interaction between time and being diagnosed or not with COVID-19 on cognition. However, being diagnosed or not with COVID-19 had a significant effect on global cognitive function (p = 0.046), verbal memory (p = 0.046), and working memory (p = 0.047). The interaction between being diagnosed with COVID-19 and cognitive impairment at baseline was significantly associated with a higher cognitive deficit (Beta = 0.81; p = 0.005). Clinical symptoms, autonomy, and depression were not associated with the cognition (p > 0.05 for all).

Conclusion: COVID-19 disease affected global cognition and memory: patients diagnosed with COVID-19 had more deficits in these domains than those without COVID-19. Further studies are necessary to clarify the variation of cognitive function among schizophrenic patients with COVID-19.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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