全身免疫炎症指数对胃癌预后有预测价值吗?

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Northern Clinics of Istanbul Pub Date : 2023-01-01 DOI:10.14744/nci.2021.71324
Hakan Uzunoglu, Selcuk Kaya
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引用次数: 1

摘要

目的:有研究报道,全身免疫炎症指数(SII)和中性粒细胞/淋巴细胞比值(NLR)可作为胃癌患者预后的预测指标。本研究旨在探讨SII和NLR在胃癌诊断和预后中的价值。方法:选取2012年1月至2018年4月在我院普外科接受胃癌诊断手术并随访的患者152例,同时选取健康对照152例。结果:胃癌患者的平均SII(989±685)和平均NLR(3.9±5.2)明显高于健康对照组(分别为433±203和1.9±0.8)(p结论:本研究结果表明,SII和NLR远不能为胃癌预后提供可靠的数据。
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Does systemic immune inflammation index have predictive value in gastric cancer prognosis?

Objective: Some studies have reported that the systemic immune inflammatory index (SII) and neutrophil/lymphocyte ratio (NLR) provide predictive data on prognosis in gastric cancer patients. In the present study, it was aimed to examine the diagnostic and prognostic values of SII and NLR in gastric cancer.

Methods: A total of 152 patients, operated with the diagnosis of gastric cancer and followed up in the General Surgery Department of our hospital between January 2012 and April 2018, and 152 healthy controls were included in the study.

Results: The mean SII (989±685) and the mean NLR (3.9±5.2) were significantly higher in gastric cancer patients than the healthy control group (433±203 and 1.9±0.8, respectively) (p<0.001 for both). In the receiver operating characteristic analyzes, a threshold value of 892 for SII had a sensitivity of 66.7% and a specificity of 62.7% in terms of predicting 5-year survival (AUC: 0.637; p=0.076; LB: 0.475; UB: 0.799; CI 95%). The 5-year survival rate was found to be significantly higher in those with a SII of above 892 than those with a SII of 892 and below (p=0.026). The 5-year mortality risk was 0.67-fold lower in those with SII above 892 (p=0.111; 95% CI 0.4-1.1).

Conclusion: The present study findings show that SII and NLR are far from providing reliable data on gastric cancer prognosis.

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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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