基于肽和拟肽聚合物的合成螺旋丝和管的结构。

IF 7.2 2区 生物学 Q1 BIOPHYSICS Quarterly Reviews of Biophysics Pub Date : 2022-03-21 DOI:10.1017/S0033583522000014
Jessalyn G Miller, Spencer A Hughes, Charles Modlin, Vincent P Conticello
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引用次数: 0

摘要

合成肽和拟肽细丝和管是一类具有广泛潜在应用的纳米材料,如药物递送、疫苗开发、合成催化剂设计、封装和能量转导。这些细丝的结构包括基于亚基螺旋排列的超分子聚合物,这些超分子聚合物可以来自基于不同结构基序的单体的自组装。近年来,对这些材料的近原子分辨率(NAR)结构分析已经对序列、局部构象、高阶结构和形态之间的关系产生了重要的见解。这种结构信息为开发新工具提供了机会,以促进合成螺旋细丝的可预测和可重复的从头设计。然而,这些研究也揭示了后一过程的几个重大障碍-最值得注意的是,由于结构空间中螺旋对称的不稳定性导致结构多态性的常见发生。本文总结了目前关于设计肽和拟肽丝状组装体结构的知识现状,重点介绍了已经解决的具有可靠原子模型的NAR结构。
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Structures of synthetic helical filaments and tubes based on peptide and peptido-mimetic polymers.
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来源期刊
Quarterly Reviews of Biophysics
Quarterly Reviews of Biophysics 生物-生物物理
CiteScore
12.90
自引率
1.60%
发文量
16
期刊介绍: Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.
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