基于肽和拟肽聚合物的合成螺旋丝和管的结构。

IF 7.6 1区 生物学 Q1 BIOLOGY BioScience Pub Date : 2022-03-21 DOI:10.1017/S0033583522000014
Jessalyn G Miller, Spencer A Hughes, Charles Modlin, Vincent P Conticello
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引用次数: 0

摘要

合成肽和拟肽细丝和管是一类具有广泛潜在应用的纳米材料,如药物递送、疫苗开发、合成催化剂设计、封装和能量转导。这些细丝的结构包括基于亚基螺旋排列的超分子聚合物,这些超分子聚合物可以来自基于不同结构基序的单体的自组装。近年来,对这些材料的近原子分辨率(NAR)结构分析已经对序列、局部构象、高阶结构和形态之间的关系产生了重要的见解。这种结构信息为开发新工具提供了机会,以促进合成螺旋细丝的可预测和可重复的从头设计。然而,这些研究也揭示了后一过程的几个重大障碍-最值得注意的是,由于结构空间中螺旋对称的不稳定性导致结构多态性的常见发生。本文总结了目前关于设计肽和拟肽丝状组装体结构的知识现状,重点介绍了已经解决的具有可靠原子模型的NAR结构。
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Structures of synthetic helical filaments and tubes based on peptide and peptido-mimetic polymers.
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来源期刊
BioScience
BioScience 生物-生物学
CiteScore
14.10
自引率
2.00%
发文量
109
审稿时长
3 months
期刊介绍: BioScience is a monthly journal that has been in publication since 1964. It provides readers with authoritative and current overviews of biological research. The journal is peer-reviewed and heavily cited, making it a reliable source for researchers, educators, and students. In addition to research articles, BioScience also covers topics such as biology education, public policy, history, and the fundamental principles of the biological sciences. This makes the content accessible to a wide range of readers. The journal includes professionally written feature articles that explore the latest advancements in biology. It also features discussions on professional issues, book reviews, news about the American Institute of Biological Sciences (AIBS), and columns on policy (Washington Watch) and education (Eye on Education).
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