用甘油磷脂替代膜脂可缓慢降低海湾战争化学暴露老兵自我报告的症状严重程度

G. Nicolson, P. C. Breeding
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引用次数: 3

摘要

背景:1991年海湾战争中接触化学物质的退伍军人很少有治疗与化学物质接触有关的条件和症状的选择。口服膜甘油磷脂膜脂替代(MLR)是一种安全有效的方法,可以缓慢地从组织中去除疏水有机分子,同时增强线粒体功能并降低与多症状疾病相关的某些体征和症状的严重程度。方法:对20名被部署到战区、暴露于环境有毒化学物质并随后被诊断为海湾战争病(GWI)的男性退伍军人进行初步开放标签研究。受试者每天口服6克甘油磷脂,持续6个月,并在不同时间使用疾病调查表自我报告100多种体征和症状的严重程度。结果:在完全遵守并完成研究的16例患者中,疲劳、疼痛、肌肉骨骼、鼻咽、呼吸、视力、睡眠、平衡、泌尿、胃肠道和化学敏感性等类别的症状严重程度逐渐显著减轻。在研究期间没有发生不良事件,全天然口服研究补充剂的耐受性非常好。结论:口服甘油磷脂的MLR似乎是一种简单、安全、潜在有效的方法,可以缓慢降低化学暴露退伍军人多种症状的严重程度。
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Membrane Lipid Replacement with Glycerolphospholipids Slowly Reduces Self-Reported Symptom Severities in Chemically Exposed Gulf War Veterans
Background: Chemically exposed veterans of the 1991 Gulf War have few options for treatment of conditions and symptoms related to their chemical exposures. Membrane Lipid Replacement (MLR) with oral membrane glycerolphospholipids is a safe and effective method for slowly removing hydrophobic organic molecules from tissues, while enhancing mitochondrial function and decreasing the severity of certain signs and symptoms associated with multi-symptom illnesses. Methods: A preliminary open-label study utilizing 20 male veterans who were deployed to combat areas, exposed to environmental toxic chemicals and subsequently diagnosed with Gulf War Illnesses (GWI) were utilized. These subjects took 6 g per day oral glycerolphospholipids for 6 months, and the severities of over 100 signs and symptoms were self-reported at various times using illness survey forms. Results: In the sixteen patients that fully complied and completed the study, there were gradual and significant reductions of symptom severities in categories related to fatigue, pain, musculoskeletal, nasopharyngeal, breathing, vision, sleep, balance, and urinary, gastrointestinal and chemical sensitivities. There were no adverse incidents during the study, and the all-natural oral study supplement was extremely well tolerated. Conclusions: MLR with oral glycerolphospholipids appears to be a simple, safe and potentially effective method of slowly reducing the severities of multiple symptoms in chemically exposed veterans.
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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