沃尔夫拉姆综合征和嗅觉功能减退患者的味觉会因重鼻气味而增强。

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES Chemical Senses Pub Date : 2023-01-01 DOI:10.1093/chemse/bjad004
Raul Alfaro, Jessica G Nicanor-Carreón, Tasha Doty, Heather Lugar, Tamara Hershey, Marta Yanina Pepino
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引用次数: 0

摘要

沃尔夫拉姆综合征是一种以糖尿病、神经变性、视力和听力丧失为特征的罕见疾病。我们最近在一个年轻的样本参与者(平均年龄 15 岁)中发现,沃尔夫拉姆综合征与嗅觉识别障碍有关,但嗅觉灵敏度和全口味觉功能正常。然而,这些感官是单独评估的,沃尔弗拉姆综合征患者嗅觉与味觉之间的相互作用是否会发生改变尚不得而知,而这正是本研究的重点。研究人员对沃尔夫拉姆综合征患者(36 人,18.2 ± 6.8 岁)和性别年龄相当的健康对照组(34 人)进行了一系列感官测试。参与者采用 "啜-吐 "法,在使用或不使用鼻夹的情况下品尝含有味觉和嗅觉刺激的溶液(蔗糖加草莓提取物、柠檬酸加柠檬提取物、氯化钠加蔬菜汤和咖啡),并使用通用标签量表对感知的味觉和反鼻嗅觉强度进行评分。参与者还完成了正丁醇检测阈值和宾夕法尼亚大学气味识别测试(UPSIT)。在蔗糖、氯化钠和咖啡溶液中,两组人的逆鼻腔嗅觉增加了味觉强度(P 值
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Enhancement of taste by retronasal odors in patients with Wolfram syndrome and decreased olfactory function.

Wolfram syndrome is a rare disease characterized by diabetes, neurodegeneration, loss of vision, and audition. We recently found, in a young sample of participants (mean age 15 years), that Wolfram syndrome was associated with impairment in smell identification with normal smell sensitivity and whole-mouth taste function. However, these senses were assessed separately, and it is unknown whether smell-taste interactions are altered in Wolfram syndrome, which was the focus of this study. Participants with Wolfram syndrome (n = 36; 18.2 ± 6.8 years) and sex-age-equivalent healthy controls (n = 34) were assessed with a battery of sensory tests. Using sip-and-spit methods, participants tasted solutions containing gustatory and olfactory stimuli (sucrose with strawberry extract, citric acid with lemon extract, sodium chloride in vegetable broth, and coffee) with and without nose clips, and rated perceived taste and retronasal smell intensities using the generalized Labeled Magnitude Scale. Participants also completed n-butanol detection thresholds and the University of Pennsylvania Smell Identification Test (UPSIT). Retronasal smell increased taste intensity of sucrose, sodium chloride, and coffee solutions similarly in both groups (P values <0.03). Compared with the control group, participants in the Wolfram group had lower UPSIT scores and reduced smell sensitivity, retronasal intensity, and saltiness (P values <0.03), but rated other taste intensities similarly when wearing the nose clip. Despite impairments in orthonasal smell identification, odor-induced taste enhancement was preserved in participants with Wolfram syndrome who still had some peripheral olfactory function. This finding suggests that odor-induced taste enhancement may be preserved in the presence of reduced olfactory intensity.

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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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