微生物群对乳腺癌激素治疗的影响。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2023-03-01 DOI:10.15698/cst2023.03.277
Safae Terrisse, Laurence Zitvogel, Guido Kroemer
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引用次数: 1

摘要

最近的观察表明,激素受体乳腺癌的发病机制和预后不仅与恶性细胞的性质有关,而且与免疫和微生物参数有关。因此,免疫监视系统延缓了激素阳性乳腺癌的发展,并有助于雌激素受体拮抗剂和芳香酶抑制剂的治疗效果。此外,局部和肠道微生物群深刻调节抗癌免疫反应,影响癌细胞的内在信号通路,影响肿瘤微环境中免疫浸润的组成和功能,调节雌激素的代谢。事实上,肠道中的特定细菌产生的酶会影响雌激素代谢物的肠肝循环,将雌激素转化为雄激素或产生雌激素样分子。对这些电路的了解还处于初级阶段,需要进一步深入分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of microbiota on breast cancer hormone therapy.

Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters. Thus, the immunosurveillance system retards the development of hormone-positive breast cancer and contributes to the therapeutic efficacy of estrogen receptor antagonists and aromatase inhibitors. Moreover, the anticancer immune response is profoundly modulated by the local and intestinal microbiota, which influences cancer cell-intrinsic signaling pathways, affects the composition and function of the immune infiltrate present in the tumor microenvironment and modulates the metabolism of estrogens. Indeed, specific bacteria in the gut produce enzymes that affect the enterohepatic cycle of estrogen metabolites, convert estrogens into androgens or generate estrogen-like molecules. The knowledge of these circuitries is in its infancy, calling for further in-depth analyses.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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