B细胞发育的突破口

Q3 Arts and Humanities Anthropology and Archeology of Eurasia Pub Date : 2016-02-08 DOI:10.1084/jem.2132insight1
Stephen Desiderio
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引用次数: 0

摘要

在B细胞发育过程中,免疫球蛋白基因的组装以有序波的形式发生。重链(Igh)位点通常首先重组,每个等位基因最多有一次机会进行生产性重排。随后,在κ (Igk)位点,单个等位基因可以进行连续的重排,允许不同的轻、重链组合进行测试,直到产生功能性的、非自我反应性的免疫球蛋白。这两波重组被一个由前b细胞受体(pre-BCR)控制的检查点分开,该检查点强制在Igh位点排除等位基因,触发增殖,并促进Igk重排。这就提出了一个问题:如果DNA切割和细胞周期进入同时开始,我们如何减轻可能发生的基因组损伤?在这期杂志上,Bednarski等人提出了一个解决方案:ragg诱导的DNA双链断裂(DSBs)抑制bcr前信号传导的一种意想不到的机制。rag诱导的dsb触发一个信号通路,最终通过转录抑制子SPIC抑制bcr前信号。
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Anthropology and Archeology of Eurasia
Anthropology and Archeology of Eurasia Arts and Humanities-History
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期刊介绍: Anthropology and Archeology of Eurasia presents scholarship from Russia, Siberia, the Caucasus, and Central Asia, the vast region that stretches from the Baltic to the Black Sea and from Lake Baikal to the Bering Strait. Each thematic issue, with a substantive introduction to the topic by the editor, features expertly translated and annotated manuscripts, articles, and book excerpts reporting fieldwork from every part of the region and theoretical studies on topics of special interest.
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