摘要:PRMT5抑制在表观遗传学上调控癌细胞的DNA损伤反应途径,并对化疗和PARP抑制增敏

Koichi Ito, Jack Carter, V. Thodima, Youyou Zhang, Monisha Sivakumar, Mu Xu, N. Bhagwat, J. Rager, Jacob Spruance, Lin Zhang, Bruce R Ruggeri, P. Scherle, K. Vaddi
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Abstract 1185: PRMT5 inhibition epigenetically regulates DNA damage response pathways in cancer cells and sensitizes to chemotherapy and PARP inhibition
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