口服心得安治疗婴幼儿眼部血管瘤的临床观察

Jing Huang, Daoman Xiang
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摘要

目的评价口服心得安治疗婴幼儿眼血管瘤的临床疗效和安全性。2016年2月至2018年4月66例婴幼儿眼部血管瘤门诊患者的前瞻性分析。根据口服心得安处方的初始剂量、维持剂量顺序及停药情况,研究分析肿瘤大小、颜色变化及不良反应,评价临床疗效及安全性。55例(83.3%)门诊患者1周内肿瘤变弱。I级疗效(无效)4例(6.1%),II级疗效(差)7例(10.6%),III级疗效(改善)9例(13.6%),IV级疗效(治愈)46例(69.7%)。平均用药时间为6.9个月。长疗程组疗效优于短疗程组,以4-12个月组疗效最好。除1例腹泻外,未见明显副作用。左右眼、性别间疗效差异无统计学意义(P>0.05)。门诊患者使用心得安治疗IH,严格控制适应症和禁忌症,临床疗效和安全性比较满意。
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Clinical Observation of Treating Infantile Ophthalmic Hemangioma by Oral Propranolol
To evaluate the clinical efficacy and safety by oral propranolol in treating infantile ophthalmichemangioma (IH). A prospective analysis of 66 infantile outpatients with ophthalmic hemangioma from Feb 2016 to Apr 2018. According to the initial dose, the order of maintenance dose and drug withdrawal of oral propranolol prescription, the tumor size, color change and adverse reactions were studied and analyzed, and the clinical efficacy and safety were evaluated. The tumors became weak within 1 week in 83.3% outpatients (55 cases). 4 (6.1%) outpatients received Grade I efficacy (ineffective), 7 (10.6%) Grade II (poor), 9 (13.6%) Grade III (improvement) and 46 (69.7%) Grade IV (cured). The average prescribed medication treatment time was 6.9 months. The curative effect of the long course groups was better than the short ones, and 4-12 months group was the best. No obvious side effect was detected except 1 diarrhea. There was no significant difference in curative effect between left and right eyes or sex (P>0.05). Propranolol was used in outpatients to treat IH, the indications and contraindications were strictly controlled and the clinical efficacy and safety were relatively satisfactory.
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