提取物淀粉样样(锯齿状截面为埃利斯)和菌根样凝胶样料样本的配方和物理稳定性比较

Sofia Eliasari
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摘要

背景:栀子中含有具有抗氧化和抗菌作用的黄酮类化合物。传统使用需要长时间的制备,因此有必要配制更实用、更耐用的制剂。在配方中选择凝胶制剂是因为它容易干燥,形成一层容易洗掉的膜,并在皮肤上提供凉爽的感觉。凝胶组分影响凝胶的稳定性。为保证凝胶的质量、安全、功效符合预期规格,并在贮存期间保持稳定,需进行稳定性试验。本研究旨在测定市场上栀子凝胶制剂与痤疮斑凝胶的物理稳定性差异,并确定具有最佳物理稳定性的栀子提取物浓度。方法:采用实验室方法对该方法进行研究。以96%乙醇为溶剂提取松皮草。以0.5% (FI)、1% (FII)、1.5% (FIII)的浓度配制成凝胶剂型。研究结果:通过感官测试、均匀性测试、pH测试、黏附测试、粘度测试、享乐测试和凝胶稳定性测试对制剂的物理稳定性进行了测试,并与市场上的凝胶进行了比较。在室温下观察制剂的物理稳定性,市售凝胶的pH值比栀子提取物偏酸。公式3的粘度较大。在稳定性测试中,从市场上的三种配方和凝胶来看,形状、颜色和气味都没有变化。
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FORMULASI DAN PERBANDINGAN UJI STABILITAS FISIK SEDIAAN GEL EKSTRAK DAUN KACAPIRING (GARDENIA JASMINOIDES ELLIS) DAN ACNES SPOT GEL DIPASARAN
Background: The gardenia jasminoides ellis contain flavonoids which have antioxidant and the antibacterial effects. Traditional use requires a long preparation, so it is necessary to formulate preparations that are more practical and durable in storage. The gel preparation was chosen in the formulation because it dries easily, forms a film that is easy to wash off and provides a cooling feeling on the skin. The gel component affects of the stability of the gel. The stability tests need to be carried out to ensure the quality, safety and efficacy of the gel meets the expected specifications and is stable during storage. The aims of the study to determine the difference in of the physical stability of the gel preparation of Gardenia jaminoides ellis and acnes spot gel on the market and determine the concentration of gardenia jasminoides ellis extract which has the best physical stability. Methods: The research of the method is experimental laboratory. Simplicia was extracted using 96% ethanol as solvent. The extract was formulated in gel dosage form with a concentration of 0.5% (FI), 1% (FII) and 1.5% (FIII). The results of study: The physical stability of the preparation tested by organoleptic, homogeneity, pH test, adhesion test, viscosity test, hedonic test and gel stability test which were compared with gels on the market. The results of the physical stability of the preparation observed at room temperature, the pH of the market gel was more acidic than the gardenia jasminoides ellis extract. The viscosity of formula 3 is higher in viscosity. In the stability test, it was seen that from the three formulas and gels on the market there was no change in shape, color and odor.
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