噻嗪类化合物的合成、表征及抑菌活性评价

Arsalan Sarmad, R. Sultana, B. Salman
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引用次数: 2

摘要

1,3 -噻嗪类化合物已被应用于立体选择性合成中,并在对映体选择性转化中作为手性配体和助剂。噻嗪具有重要意义,因为它们是合成头孢菌素(3,6-二氢- 2h - 1,3-噻嗪)的前体,然后转化为噻嗪衍生物(杂环化合物)。因此,人们认为将查尔酮部分与噻嗪衍生物结合在一个分子框架中,观察这些环的生物活性,以及它们对生物活性的加性作用,如抗细菌和抗真菌活性。
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Synthesis, Characterize and Evaluation of anti-bacterial and anti-fungal activity of thiazines
1,3 – Thiazines have been applied as useful starting materials in the stereo selective synthesis of compounds of pharmacological interest and they have served as chiral ligants and auxiliaries in enantioselective transformation. The thiazines are of great importance because they act as precursor for the synthesis of Cephalosporins (3,6-dihydro-2H-,1,3-thiazine) and then converted to the thiazine derivatives (an heterocyclic compounds). Therefore, it was thought to combine chalcones moiety to thiazine derivative together in a molecular frame work to see the biological activities, additive effort of these rings towards biological activities like Anti- bacterial and Anti- fungal activities.
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