伊朗鼻咽肿瘤的流行病学和组织病理学。

Ali Safavi Naini, Mohammad Mehdi Rostami, Fatemeh Shojaeian, Mehdi Azizmohammad Looha, Ali Ghanbari Motlagh, Amir Ali Safavi, Seyed Amir Ahmad Safavi-Naini
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引用次数: 0

摘要

前言:本研究旨在研究2003 - 2017年伊朗鼻咽癌(NPC)和鼻咽癌(NPN)的发病趋势、组织学特征、地理分布及特点。材料和方法:卫生和医学教育部从各省相应大学收集NPN病例,并将其储存在伊朗国家癌症登记处(INCR)数据库中。Joinpoint项目计算了平均年变化百分比(AAPC)及其95%置信区间(CI)。跳跃模型最大限度地降低了INCR变换的干扰效应。结果:2003-2010年至2014-2017年共报告NPN病例3653例,平均年龄49.04±18.31岁,男女比2.15。2017年,每10万人年的年龄标准化发病率(ASIR)女性为0.30,男性为0.68。虽然2003-2017年期间,NPN的ASIR/100,000从0.35上升到0.49,但AAPC的趋势不变,为-2% (95% CI: -4.8%至0.9%)。70岁以上人群发病率最高(1.56/10万)。NPC占NPNs的77.1%,且呈恒定模式(AAPC CI: -5.7%至0.2%),而非角化性鳞状细胞癌显著增加(AAPC CI: 2.3%至24.5%)。结论:鼻咽癌在伊朗很少见,2003年至2017年鼻咽癌发病率保持不变,与之前报道的上升趋势不同。然而,非角化性鳞状细胞癌表现出显著的增加,需要进一步的研究来检验爱泼斯坦-巴尔病毒在这种增长速度中的作用。
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Epidemiology and Histopathology of Nasopharyngeal Neoplasms in Iran.

Introduction: This study aimed to study the trend, histologic pattern, geographical distribution, and characteristics of nasopharyngeal carcinoma (NPC) and nasopharyngeal neoplasms (NPN) from 2003 to 2017 in Iran.

Materials and methods: The Ministry of Health and Medical Education collected NPN cases from the corresponding university in each province and stored them in Iran National Cancer Registry (INCR) database. The Joinpoint program calculated the average annual percent change (AAPC) and its 95% confidence interval (CI). The jump model minimized the interfering effect of INCR transformation.

Results: 3653 NPN cases were reported between 2003-2010 and 2014-2017, with a mean age of 49.04 ± 18.31 years and a male-to-female ratio of 2.15. The age-standardized incidence rate (ASIR) per 100,000 person-years was 0.30 for females and 0.68 for males in 2017. Although the ASIR/100,000 of NPN raised from 0.35 to 0.49 during 2003-2017, the trend was constant with an AAPC of -2% (95% CI: -4.8% to 0.9%). The age-specific incidence rate was highest in the older than 70 population (1.56/100,000). NPC formed 77.1% of NPNs and showed a constant pattern (AAPC CI: -5.7% to 0.2%), in contrast to the significant increase of non-keratinizing squamous cell carcinoma (AAPC CI: 2.3%to 24.5%).

Conclusions: Nasopharynx cancer is rare in Iran, and NPC incidence remained constant from 2003 to 2017, unlike previously reported rising trend. However, non-keratinizing squamous cell carcinoma exhibited a significant increase, and future studies are needed to examine the role of the Epstein-Barr virus on this growth rate.

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来源期刊
Iranian Journal of Otorhinolaryngology
Iranian Journal of Otorhinolaryngology Medicine-Otorhinolaryngology
CiteScore
1.30
自引率
0.00%
发文量
72
审稿时长
12 weeks
期刊最新文献
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