生活在高海拔地区的不同年龄土著妇女血细胞与代谢变量的关系

Yahvé González-Quintanilla , Estela Cuevas , Rosalía Cruz-Lumbreras , Porfrio Carrillo-Castilla , Jorge Rodríguez-Antolín , Margarita Martínez-Gómez
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摘要

有研究发现血细胞浓度与代谢改变呈正相关,提示应将血细胞浓度作为代谢综合征的一个组成部分。然而,这些研究都是在低海拔地区进行的,尚不清楚这种关系是否在高海拔地区维持,在那里,低气压和高缺氧会影响红细胞的数量和代谢改变的存在。本研究的目的是确定生活在海拔2500米以上的Ixtenco-Tlaxcala的Otomi妇女的红细胞和代谢变量之间的关系。方法。测量了309名妇女的身体质量指数(BMI)、总胆固醇、甘油三酯浓度和全血细胞计数。通过相关性和二元逻辑回归分析数据。结果。BMI与红细胞、血红蛋白浓度及红细胞压积呈正相关。与年龄无关,超重/肥胖和低脂血症的女性患红血病的风险很大,而患贫血的风险很低。讨论。血细胞浓度与肥胖/二脂血症的关系受海拔的影响。
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Relación entre células sanguíneas y variables metabólicas en mujeres indígenas de diferentes edades que viven a gran altitud

Some studies have found a positive relationship between the concentration of blood cells and metabolic alterations, suggesting that the concentration of blood cells should be included as a component of metabolic syndrome. However, these studies have been done at a low altitude, and it is unknown if this relationship is maintained at a high altitude, where the low atmospheric pressure and the high hypoxia affect the number of red cells and the presence of metabolic alterations. The aim of the present study was to determine the relationship between red blood cells and metabolic variables in Otomi women from Ixtenco-Tlaxcala living at 2500 meters above sea level. METHODS. The body mass index (BMI), concentration of total cholesterol, triglycerides, and complete blood count were measured in 309 women. Data were analyzed through correlations and binary logistic regressions. RESULTS.The BMI was positively correlated with the concentration of erythrocytes and hemoglobin, as well as with hematocrit. Independently of the age, women with overweight/obesity and dislipidemias have a big risk to have erythrocitosis, and low risk to have anemia. DISCUSSION. The relationship between the concentration of blood cells and obesity/ dislipidemias is affected by the altitude.

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