Bell Palsy:事实与当前研究展望。

IF 2.7 4区 医学 Q3 NEUROSCIENCES CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871527322666230321120618
Jayaraman Rajangam, Arun Prasath Lakshmanan, K Umamaheswara Rao, D Jayashree, Rajan Radhakrishnan, B Roshitha, Palanisamy Sivanandy, M Jyothi Sravani, K Hanna Pravalika
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引用次数: 0

摘要

Bell麻痹是一种非进行性神经疾病,其特征是同侧第七脑神经麻痹的急性发作。患有这种面瘫的人会出现一侧面部下垂,有时还会同时出现两侧下垂。这种情况的特点是突然发作的面瘫,并伴有临床特征,如轻度发烧、耳后疼痛、味觉障碍、多动、面部变化、流口水或眼睛干燥。流行病学证据表明,每10万人中每年有15至23人受到影响,复发率为12%。它可能是由病毒性炎症引起的第七脑神经缺血性压迫引起的。孕妇、糖尿病患者和呼吸道感染者比普通人群更容易出现面瘫。免疫、病毒和缺血性途径都被认为在贝尔麻痹的发展中发挥作用,但确切原因尚不清楚。然而,有证据表明,贝尔的遗传性麻痹倾向是一个公共卫生问题,对患者及其家人的影响更大。延迟或未经治疗的Bell麻痹可能会增加面部损伤的风险,并对患者的生活质量产生负面影响。对于管理,抗病毒药物,如阿昔洛韦和伐昔洛韦,以及类固醇治疗是推荐的。因此,早期诊断并治疗不确定的病因是至关重要的。本文综述了Bell麻痹症的机制方法和新出现的医学观点。
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Bell Palsy: Facts and Current Research Perspectives.

Bell palsy is a non-progressive neurological condition characterized by the acute onset of ipsilateral seventh cranial nerve paralysis. People who suffer from this type of facial paralysis develop a droop on one side of their face, or sometimes both. This condition is distinguished by a sudden onset of facial paralysis accompanied by clinical features such as mild fever, postauricular pain, dysgeusia, hyperacusis, facial changes, and drooling or dry eyes. Epidemiological evidence suggests that 15 to 23 people per 100,000 are affected each year, with a recurrence rate of 12%. It could be caused by ischaemic compression of the seventh cranial nerve, which could be caused by viral inflammation. Pregnant women, people with diabetes, and people with respiratory infections are more likely to have facial paralysis than the general population. Immune, viral, and ischemic pathways are all thought to play a role in the development of Bell paralysis, but the exact cause is unknown. However, there is evidence that Bell's hereditary proclivity to cause paralysis is a public health issue that has a greater impact on patients and their families. Delay or untreated Bell paralysis may contribute to an increased risk of facial impairment, as well as a negative impact on the patient's quality of life. For management, antiviral agents such as acyclovir and valacyclovir, and steroid treatment are recommended. Thus, early diagnosis accompanied by treatment of the uncertain etiology of the disorder is crucial. This paper reviews mechanistic approaches, and emerging medical perspectives on recent developments that encounter Bell palsy disorder.

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来源期刊
CiteScore
5.10
自引率
3.30%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Aims & Scope CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. CNS & Neurological Disorders - Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. The journal also accepts for publication original research articles, letters, reviews and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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